Chronic periodontal disease, periodontal pathogen colonization, & increased risk of precancerous gastric lesions

Jinghua Sun, Min Zhou, Christian R. Salazar, Rosemary Hays, Sukhleen Bedi, Yu Chen, Yihong Li

Research output: Contribution to journalArticle

Abstract

Background: This study assesses the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (PLGC) in a clinical setting. Methods: Included were 35 newly diagnosed patients with PLGC and 70 age-matched individuals without PLGC. A fullmouth intraoral examination was performed to assess periodontal conditions. Stimulated whole saliva and pooled plaque samples were collected to evaluate colonization by Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans and to characterize oral microbial diversity in saliva and dental plaque. Results: Compared with the control group, patients with PLGC experienced higher prevalence of bleeding on probing (31.5% versus 22.4%; P <0.05), higher levels of T. denticola (P <0.01) and A. actinomycetemcomitans (P <0.01), and less bacterial diversity in their saliva (P <0.01). The final multivariate logistic regression model consisting of all key sociodemographic characteristics, oral health behavioral factors, and periodontal assessments revealed that elevated colonization with periodontal pathogens, specifically T. forsythia, T. denticola, and A. actinomycetemcomitans, decreased bacterial diversity in dental plaque, and not flossing teeth regularly was a significant predictor of increased risk of PLGC (P = 0.022). Conclusion: Findings of the present study provide new evidence suggesting that periodontal pathogen burdens and bacterial diversity in the oral cavity are important factors contributing to a potentially increased risk of developing precancerous gastric lesions.

Original languageEnglish (US)
Pages (from-to)1124-1134
Number of pages11
JournalJournal of Periodontology
Volume88
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Periodontal Diseases
Stomach Neoplasms
Treponema denticola
Stomach
Chronic Disease
Aggregatibacter actinomycetemcomitans
Saliva
Dental Plaque
Logistic Models
Porphyromonas gingivalis
Oral Health
Mouth
Tooth
Hemorrhage
Control Groups
Tannerella forsythia

Keywords

  • Microbiology
  • Microbiota
  • Periodontal diseases
  • Precancerous conditions
  • Risk factors

ASJC Scopus subject areas

  • Periodontics

Cite this

Chronic periodontal disease, periodontal pathogen colonization, & increased risk of precancerous gastric lesions. / Sun, Jinghua; Zhou, Min; Salazar, Christian R.; Hays, Rosemary; Bedi, Sukhleen; Chen, Yu; Li, Yihong.

In: Journal of Periodontology, Vol. 88, No. 11, 01.11.2017, p. 1124-1134.

Research output: Contribution to journalArticle

Sun, Jinghua ; Zhou, Min ; Salazar, Christian R. ; Hays, Rosemary ; Bedi, Sukhleen ; Chen, Yu ; Li, Yihong. / Chronic periodontal disease, periodontal pathogen colonization, & increased risk of precancerous gastric lesions. In: Journal of Periodontology. 2017 ; Vol. 88, No. 11. pp. 1124-1134.
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abstract = "Background: This study assesses the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (PLGC) in a clinical setting. Methods: Included were 35 newly diagnosed patients with PLGC and 70 age-matched individuals without PLGC. A fullmouth intraoral examination was performed to assess periodontal conditions. Stimulated whole saliva and pooled plaque samples were collected to evaluate colonization by Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans and to characterize oral microbial diversity in saliva and dental plaque. Results: Compared with the control group, patients with PLGC experienced higher prevalence of bleeding on probing (31.5{\%} versus 22.4{\%}; P <0.05), higher levels of T. denticola (P <0.01) and A. actinomycetemcomitans (P <0.01), and less bacterial diversity in their saliva (P <0.01). The final multivariate logistic regression model consisting of all key sociodemographic characteristics, oral health behavioral factors, and periodontal assessments revealed that elevated colonization with periodontal pathogens, specifically T. forsythia, T. denticola, and A. actinomycetemcomitans, decreased bacterial diversity in dental plaque, and not flossing teeth regularly was a significant predictor of increased risk of PLGC (P = 0.022). Conclusion: Findings of the present study provide new evidence suggesting that periodontal pathogen burdens and bacterial diversity in the oral cavity are important factors contributing to a potentially increased risk of developing precancerous gastric lesions.",
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AB - Background: This study assesses the association between periodontal pathogen colonization and the potential risk of developing precancerous lesions of gastric cancer (PLGC) in a clinical setting. Methods: Included were 35 newly diagnosed patients with PLGC and 70 age-matched individuals without PLGC. A fullmouth intraoral examination was performed to assess periodontal conditions. Stimulated whole saliva and pooled plaque samples were collected to evaluate colonization by Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans and to characterize oral microbial diversity in saliva and dental plaque. Results: Compared with the control group, patients with PLGC experienced higher prevalence of bleeding on probing (31.5% versus 22.4%; P <0.05), higher levels of T. denticola (P <0.01) and A. actinomycetemcomitans (P <0.01), and less bacterial diversity in their saliva (P <0.01). The final multivariate logistic regression model consisting of all key sociodemographic characteristics, oral health behavioral factors, and periodontal assessments revealed that elevated colonization with periodontal pathogens, specifically T. forsythia, T. denticola, and A. actinomycetemcomitans, decreased bacterial diversity in dental plaque, and not flossing teeth regularly was a significant predictor of increased risk of PLGC (P = 0.022). Conclusion: Findings of the present study provide new evidence suggesting that periodontal pathogen burdens and bacterial diversity in the oral cavity are important factors contributing to a potentially increased risk of developing precancerous gastric lesions.

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