Chronic antidepressant treatment impairs the acquisition of fear extinction

Nesha S. Burghardt, Torfi Sigurdsson, Jack M. Gorman, Bruce S. McEwen, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Background: Like fear conditioning, the acquisition phase of extinction involves new learning that is mediated by the amygdala. During extinction training, the conditioned stimulus is repeatedly presented in the absence of the unconditioned stimulus, and the expression of previously learned fear gradually becomes suppressed. Our previous study revealed that chronic treatment with a selective serotonin reuptake inhibitor (SSRI) impairs the acquisition of auditory fear conditioning. To gain further insight into how SSRIs affect fear learning, we tested the effects of chronic SSRI treatment on the acquisition of extinction. Methods: Rats were treated chronically (22 days) or subchronically (9 days) with the SSRI citalopram (10 mg/kg/day) before extinction training. The results were compared with those after chronic and subchronic treatment with tianeptine (10 mg/kg/day), an antidepressant with a different method of action. The expression of the NR2B subunit of the N-methyl-D-aspartate receptor in the amygdala was examined after behavioral testing. Results: Chronic but not subchronic administration of citalopram impaired the acquisition of extinction and downregulated the NR2B subunit of the N-methyl-D-aspartate receptor in the lateral and basal nuclei of the amygdala. Similar behavioral and molecular changes were found with tianeptine treatment. Conclusions: These results provide further evidence that chronic antidepressant treatment can impair amygdala-dependent learning. Our findings are consistent with a role for glutamatergic neurotransmission in the final common pathway of antidepressant treatment.

Original languageEnglish (US)
Pages (from-to)1078-1086
Number of pages9
JournalBiological Psychiatry
Volume73
Issue number11
DOIs
StatePublished - Jun 1 2013

Fingerprint

tianeptine
Antidepressive Agents
Fear
Serotonin Uptake Inhibitors
Amygdala
Citalopram
Learning
Synaptic Transmission
Down-Regulation
Psychological Extinction
Basolateral Nuclear Complex
NR2B NMDA receptor
Conditioning (Psychology)

Keywords

  • Amygdala
  • citalopram
  • extinction
  • fear conditioning
  • NR2B subunit
  • SSRI

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Chronic antidepressant treatment impairs the acquisition of fear extinction. / Burghardt, Nesha S.; Sigurdsson, Torfi; Gorman, Jack M.; McEwen, Bruce S.; Ledoux, Joseph.

In: Biological Psychiatry, Vol. 73, No. 11, 01.06.2013, p. 1078-1086.

Research output: Contribution to journalArticle

Burghardt, Nesha S. ; Sigurdsson, Torfi ; Gorman, Jack M. ; McEwen, Bruce S. ; Ledoux, Joseph. / Chronic antidepressant treatment impairs the acquisition of fear extinction. In: Biological Psychiatry. 2013 ; Vol. 73, No. 11. pp. 1078-1086.
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