Child externalizing behavior problems linked to genetic and non-genetic variation in dental caries

Michael F. Lorber, Amy Slep, Richard Heyman, Walter A. Bretz

Research output: Contribution to journalArticle

Abstract

The association of environmental and genetic variation in caries with child externalizing behavior problems (inattention, hyperactivity, impulsivity, and defiance) was studied in a sample of 239 pairs of 3- to 8-year-old impoverished Brazilian twins. It was hypothesized that externalizing problems would show a stronger positive association with environmental than genetic variation in caries. Univariate twin models were estimated to parse variation in caries into three components: additive genetic (A), shared environment (C) and non-shared environment/error (E). Age-adjusted associations between externalizing problems and each variance component were tested. Contrary to the hypothesis, modest but very consistent negative associations were found between externalizing problems and both genetic and environmental variation in caries. Mutans streptococci and sweetness preference did not explain the negative associations of caries and externalizing problems. Externalizing problems in non-medicated children were associated with less dental decay that could be explained by both genetic and environmental factors.

Original languageEnglish (US)
Pages (from-to)475-481
Number of pages7
JournalCaries Research
Volume48
Issue number5
DOIs
StatePublished - Apr 16 2014

Fingerprint

Dental Caries
Child Behavior
Streptococcus mutans
Impulsive Behavior

Keywords

  • Attention deficit
  • Childhood caries
  • Environment
  • Externalizing
  • Genetic
  • Hyperactivity
  • Impulsivity
  • Oppositional-defiant
  • Twins

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Child externalizing behavior problems linked to genetic and non-genetic variation in dental caries. / Lorber, Michael F.; Slep, Amy; Heyman, Richard; Bretz, Walter A.

In: Caries Research, Vol. 48, No. 5, 16.04.2014, p. 475-481.

Research output: Contribution to journalArticle

@article{3ce58962ffc44a12a9539df88ca56f3f,
title = "Child externalizing behavior problems linked to genetic and non-genetic variation in dental caries",
abstract = "The association of environmental and genetic variation in caries with child externalizing behavior problems (inattention, hyperactivity, impulsivity, and defiance) was studied in a sample of 239 pairs of 3- to 8-year-old impoverished Brazilian twins. It was hypothesized that externalizing problems would show a stronger positive association with environmental than genetic variation in caries. Univariate twin models were estimated to parse variation in caries into three components: additive genetic (A), shared environment (C) and non-shared environment/error (E). Age-adjusted associations between externalizing problems and each variance component were tested. Contrary to the hypothesis, modest but very consistent negative associations were found between externalizing problems and both genetic and environmental variation in caries. Mutans streptococci and sweetness preference did not explain the negative associations of caries and externalizing problems. Externalizing problems in non-medicated children were associated with less dental decay that could be explained by both genetic and environmental factors.",
keywords = "Attention deficit, Childhood caries, Environment, Externalizing, Genetic, Hyperactivity, Impulsivity, Oppositional-defiant, Twins",
author = "Lorber, {Michael F.} and Amy Slep and Richard Heyman and Bretz, {Walter A.}",
year = "2014",
month = "4",
day = "16",
doi = "10.1159/000358100",
language = "English (US)",
volume = "48",
pages = "475--481",
journal = "Caries Research",
issn = "0008-6568",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Child externalizing behavior problems linked to genetic and non-genetic variation in dental caries

AU - Lorber, Michael F.

AU - Slep, Amy

AU - Heyman, Richard

AU - Bretz, Walter A.

PY - 2014/4/16

Y1 - 2014/4/16

N2 - The association of environmental and genetic variation in caries with child externalizing behavior problems (inattention, hyperactivity, impulsivity, and defiance) was studied in a sample of 239 pairs of 3- to 8-year-old impoverished Brazilian twins. It was hypothesized that externalizing problems would show a stronger positive association with environmental than genetic variation in caries. Univariate twin models were estimated to parse variation in caries into three components: additive genetic (A), shared environment (C) and non-shared environment/error (E). Age-adjusted associations between externalizing problems and each variance component were tested. Contrary to the hypothesis, modest but very consistent negative associations were found between externalizing problems and both genetic and environmental variation in caries. Mutans streptococci and sweetness preference did not explain the negative associations of caries and externalizing problems. Externalizing problems in non-medicated children were associated with less dental decay that could be explained by both genetic and environmental factors.

AB - The association of environmental and genetic variation in caries with child externalizing behavior problems (inattention, hyperactivity, impulsivity, and defiance) was studied in a sample of 239 pairs of 3- to 8-year-old impoverished Brazilian twins. It was hypothesized that externalizing problems would show a stronger positive association with environmental than genetic variation in caries. Univariate twin models were estimated to parse variation in caries into three components: additive genetic (A), shared environment (C) and non-shared environment/error (E). Age-adjusted associations between externalizing problems and each variance component were tested. Contrary to the hypothesis, modest but very consistent negative associations were found between externalizing problems and both genetic and environmental variation in caries. Mutans streptococci and sweetness preference did not explain the negative associations of caries and externalizing problems. Externalizing problems in non-medicated children were associated with less dental decay that could be explained by both genetic and environmental factors.

KW - Attention deficit

KW - Childhood caries

KW - Environment

KW - Externalizing

KW - Genetic

KW - Hyperactivity

KW - Impulsivity

KW - Oppositional-defiant

KW - Twins

UR - http://www.scopus.com/inward/record.url?scp=84900880454&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900880454&partnerID=8YFLogxK

U2 - 10.1159/000358100

DO - 10.1159/000358100

M3 - Article

VL - 48

SP - 475

EP - 481

JO - Caries Research

JF - Caries Research

SN - 0008-6568

IS - 5

ER -