Chemotactic signaling, microglia, and Alzheimer's disease senile plaques: Is there a connection?

Magdalena Luca, Alexandra Chavez-Ross, Leah Edelstein-Keshet, Alex Mogilner

Research output: Contribution to journalArticle

Abstract

Chemotactic cells known as microglia are involved in the inflammation associated with pathology in Alzheimer's disease (AD). We investigate conditions that lead to aggregation of microglia and formation of local accumulations of chemicals observed in AD senile plaques. We develop a model for chemotaxis in response to a combination of chemoattractant and chemorepellent signaling chemicals. Linear stability analysis and numerical simulations of the model predict that periodic patterns in cell and chemical distributions can evolve under local attraction, long-ranged repulsion, and other constraints on concentrations and diffusion coefficients of the chemotactic signals. Using biological parameters from the literature, we compare and discuss the applicability of this model to actual processes in AD.

Original languageEnglish (US)
Pages (from-to)693-730
Number of pages38
JournalBulletin of Mathematical Biology
Volume65
Issue number4
DOIs
StatePublished - Jul 2003

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Alzheimer's Disease
Amyloid Plaques
neuroglia
Microglia
Alzheimer disease
Alzheimer Disease
chemotaxis
Linear stability analysis
Inflammation
chemoattractants
Chemotaxis
Chemotactic Factors
Linear Stability Analysis
Cell
Pathology
pathology
stability analysis
diffusivity
Diffusion Coefficient
simulation models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Chemotactic signaling, microglia, and Alzheimer's disease senile plaques : Is there a connection? / Luca, Magdalena; Chavez-Ross, Alexandra; Edelstein-Keshet, Leah; Mogilner, Alex.

In: Bulletin of Mathematical Biology, Vol. 65, No. 4, 07.2003, p. 693-730.

Research output: Contribution to journalArticle

Luca, Magdalena ; Chavez-Ross, Alexandra ; Edelstein-Keshet, Leah ; Mogilner, Alex. / Chemotactic signaling, microglia, and Alzheimer's disease senile plaques : Is there a connection?. In: Bulletin of Mathematical Biology. 2003 ; Vol. 65, No. 4. pp. 693-730.
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