Charge splitters and charge transport junctions based on guanine quadruplexes

Ruojie Sha, Limin Xiang, Chaoren Liu, Alexander Balaeff, Yuqi Zhang, Peng Zhang, Yueqi Li, David N. Beratan, Nongjian Tao, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

Self-assembling circuit elements, such as current splitters or combiners at the molecular scale, require the design of building blocks with three or more terminals. A promising material for such building blocks is DNA, wherein multiple strands can self-assemble into multi-ended junctions, and nucleobase stacks can transport charge over long distances. However, nucleobase stacking is often disrupted at junction points, hindering electric charge transport between the two terminals of the junction. Here, we show that a guanine-quadruplex (G4) motif can be used as a connector element for a multi-ended DNA junction. By attaching specific terminal groups to the motif, we demonstrate that charges can enter the structure from one terminal at one end of a three-way G4 motif, and can exit from one of two terminals at the other end with minimal carrier transport attenuation. Moreover, we study four-way G4 junction structures by performing theoretical calculations to assist in the design and optimization of these connectors.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalNature Nanotechnology
DOIs
StateAccepted/In press - Feb 26 2018

Fingerprint

guanines
Guanine
Charge transfer
DNA
Electric charge
Carrier transport
connectors
deoxyribonucleic acid
Networks (circuits)
electric charge
assembling
strands
attenuation
optimization

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Charge splitters and charge transport junctions based on guanine quadruplexes. / Sha, Ruojie; Xiang, Limin; Liu, Chaoren; Balaeff, Alexander; Zhang, Yuqi; Zhang, Peng; Li, Yueqi; Beratan, David N.; Tao, Nongjian; Seeman, Nadrian.

In: Nature Nanotechnology, 26.02.2018, p. 1-6.

Research output: Contribution to journalArticle

Sha, R, Xiang, L, Liu, C, Balaeff, A, Zhang, Y, Zhang, P, Li, Y, Beratan, DN, Tao, N & Seeman, N 2018, 'Charge splitters and charge transport junctions based on guanine quadruplexes', Nature Nanotechnology, pp. 1-6. https://doi.org/10.1038/s41565-018-0070-x
Sha, Ruojie ; Xiang, Limin ; Liu, Chaoren ; Balaeff, Alexander ; Zhang, Yuqi ; Zhang, Peng ; Li, Yueqi ; Beratan, David N. ; Tao, Nongjian ; Seeman, Nadrian. / Charge splitters and charge transport junctions based on guanine quadruplexes. In: Nature Nanotechnology. 2018 ; pp. 1-6.
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AU - Zhang, Peng

AU - Li, Yueqi

AU - Beratan, David N.

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