Characterization of two apertures microfluidic probe

Mohammadali Safavieh, Mohammad A. Qasaimeh, Roozbeh Safavieh, David Juncker

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The Microfluidic probe (MFP) is a mobile channel-less microfluidic system where a liquid is injected from one aperture into one open space and re-aspirated from a second aperture at a higher aspiration flow rate forming a Hydodynami-cally Confined Stream (HCS). In this work, we characterize both analytically and numerically the geometry of the HCS and the shear stress at the bottom substrate with respect to the ratio of aspiration to injection flow rates, gap size, and the diffusion coefficients of the injected liquid in the solute. The finite element method is used to simulate numerically the flow confinement, and dimensionless analysis is employed to characterize the concentration and shear stress profiles. We found that width and length of the HCS increases linearly with increasing gap size, and it shrinks linearly with respect to the ratio of aspiration to injection flow rates. Thanks to the establishment of the scaling laws and the numerical model we developed here, the parameters of the MFP can be predicted easily through simulation instead of having to determine them experimentally by trial and error.

Original languageEnglish (US)
Title of host publication14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Pages369-371
Number of pages3
StatePublished - Dec 1 2010
Event14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands
Duration: Oct 3 2010Oct 7 2010

Publication series

Name14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
Volume1

Other

Other14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
CountryNetherlands
CityGroningen
Period10/3/1010/7/10

Keywords

  • CFD analysis
  • Hydrodynamic flow stream
  • Microfluidic probe
  • Single cell detachment

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Safavieh, M., Qasaimeh, M. A., Safavieh, R., & Juncker, D. (2010). Characterization of two apertures microfluidic probe. In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 369-371). (14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010; Vol. 1).