Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas

Mathew B. Rogers, Kristen M. Gulino, Robert B. Tesh, Lijia Cui, Adam Fitch, Thomas R. Unnasch, Vsevolod L. Popov, Amelia P.A. Travassos da Rosa, Hilda Guzman, Jean Paul Carrera, Nikos Vasilakis, Elodie Ghedin

Research output: Contribution to journalArticle

Abstract

The Bunyaviridae family is made up of a diverse range of viruses, some of which cause disease and are a cause for concern in human and veterinary health. Here, we report the genomic and antigenic characterization of five previously uncharacterized bunyaviruses. Based on their ultrastructure, antigenic relationships and phylogenomic relationships, the five viruses are classified as members of the Orthobunyavirus genus. Three are viruses in the California encephalitis virus serogroup and are related to Trivittatus virus; the two others are most similar to the Mermet virus in the Simbu serogroup, and to the Tataguine virus, which is not currently assigned to a serogroup. Each of these five viruses was pathogenic to newborn mice, indicating their potential to cause illness in humans and other animals.

Original languageEnglish (US)
Article number000899
Pages (from-to)2258-2266
Number of pages9
JournalJournal of General Virology
Volume98
Issue number9
DOIs
StatePublished - Sep 1 2017

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Orthobunyavirus
Bunyaviridae
Viruses
Simbu virus
California Encephalitis Viruses
Health

Keywords

  • Bunyaviridae
  • California encephalitis virus serogroup
  • Genome sequence
  • Mermet virus
  • Orthobunyavirus
  • Tataguine virus

ASJC Scopus subject areas

  • Virology

Cite this

Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas. / Rogers, Mathew B.; Gulino, Kristen M.; Tesh, Robert B.; Cui, Lijia; Fitch, Adam; Unnasch, Thomas R.; Popov, Vsevolod L.; Travassos da Rosa, Amelia P.A.; Guzman, Hilda; Carrera, Jean Paul; Vasilakis, Nikos; Ghedin, Elodie.

In: Journal of General Virology, Vol. 98, No. 9, 000899, 01.09.2017, p. 2258-2266.

Research output: Contribution to journalArticle

Rogers, MB, Gulino, KM, Tesh, RB, Cui, L, Fitch, A, Unnasch, TR, Popov, VL, Travassos da Rosa, APA, Guzman, H, Carrera, JP, Vasilakis, N & Ghedin, E 2017, 'Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas', Journal of General Virology, vol. 98, no. 9, 000899, pp. 2258-2266. https://doi.org/10.1099/jgv.0.000899
Rogers, Mathew B. ; Gulino, Kristen M. ; Tesh, Robert B. ; Cui, Lijia ; Fitch, Adam ; Unnasch, Thomas R. ; Popov, Vsevolod L. ; Travassos da Rosa, Amelia P.A. ; Guzman, Hilda ; Carrera, Jean Paul ; Vasilakis, Nikos ; Ghedin, Elodie. / Characterization of five unclassified orthobunyaviruses (Bunyaviridae) from Africa and the Americas. In: Journal of General Virology. 2017 ; Vol. 98, No. 9. pp. 2258-2266.
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