Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin

Emilie Louvet, Piergiorgio Percipalle

    Research output: Contribution to journalReview article

    Abstract

    Recent years have witnessed a new turn in the field of gene expression regulation. Actin and an ever-growing family of actin-associated proteins have been accepted as members of the nuclear crew, regulating eukaryotic gene transcription. In complex with heterogeneous nuclear ribonucleoproteins and certain myosin species, actin has been shown to be an important regulator in RNA polymerase II transcription. Furthermore, actin-based molecular motors are believed to facilitate RNA polymerase I transcription and possibly downstream events during rRNA biogenesis. Probably these findings represent the tip of the iceberg of a rapidly expanding area within the functional architecture of the cell nucleus. Further studies will contribute to clarify how actin mediates nuclear functions with a glance to cytoplasmic signalling. These discoveries have the potential to define novel regulatory networks required to control gene expression at multiple levels.

    Original languageEnglish (US)
    Pages (from-to)107-147
    Number of pages41
    JournalInternational Review of Cell and Molecular Biology
    Volume272
    Issue numberC
    DOIs
    StatePublished - Dec 1 2008

    Fingerprint

    Myosins
    Gene expression
    Actins
    Gene Expression
    Transcription
    Gene expression regulation
    Heterogeneous-Nuclear Ribonucleoproteins
    RNA Polymerase I
    RNA Polymerase II
    Gene Expression Regulation
    Cell Nucleus
    Genes
    Cells
    Proteins

    Keywords

    • Chromatin regulation
    • Gene expression
    • Molecular motors
    • Nuclear actin
    • Nuclear myosin
    • Nuclear structure
    • rRNA biogenesis
    • Transcription

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology
    • Molecular Biology

    Cite this

    Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin. / Louvet, Emilie; Percipalle, Piergiorgio.

    In: International Review of Cell and Molecular Biology, Vol. 272, No. C, 01.12.2008, p. 107-147.

    Research output: Contribution to journalReview article

    Louvet, Emilie ; Percipalle, Piergiorgio. / Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin. In: International Review of Cell and Molecular Biology. 2008 ; Vol. 272, No. C. pp. 107-147.
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