Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin

Emilie Louvet, Piergiorgio Percipalle

Research output: Contribution to journalReview article

Abstract

Recent years have witnessed a new turn in the field of gene expression regulation. Actin and an ever-growing family of actin-associated proteins have been accepted as members of the nuclear crew, regulating eukaryotic gene transcription. In complex with heterogeneous nuclear ribonucleoproteins and certain myosin species, actin has been shown to be an important regulator in RNA polymerase II transcription. Furthermore, actin-based molecular motors are believed to facilitate RNA polymerase I transcription and possibly downstream events during rRNA biogenesis. Probably these findings represent the tip of the iceberg of a rapidly expanding area within the functional architecture of the cell nucleus. Further studies will contribute to clarify how actin mediates nuclear functions with a glance to cytoplasmic signalling. These discoveries have the potential to define novel regulatory networks required to control gene expression at multiple levels.

Original languageEnglish (US)
Pages (from-to)107-147
Number of pages41
JournalInternational Review of Cell and Molecular Biology
Volume272
Issue numberC
DOIs
StatePublished - Dec 1 2008

Fingerprint

Myosins
Gene expression
Actins
Gene Expression
Transcription
Gene expression regulation
Heterogeneous-Nuclear Ribonucleoproteins
RNA Polymerase I
RNA Polymerase II
Gene Expression Regulation
Cell Nucleus
Genes
Cells
Proteins

Keywords

  • Chromatin regulation
  • Gene expression
  • Molecular motors
  • Nuclear actin
  • Nuclear myosin
  • Nuclear structure
  • rRNA biogenesis
  • Transcription

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin. / Louvet, Emilie; Percipalle, Piergiorgio.

In: International Review of Cell and Molecular Biology, Vol. 272, No. C, 01.12.2008, p. 107-147.

Research output: Contribution to journalReview article

@article{07345ad81ea4421b8a557d971cd18928,
title = "Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin",
abstract = "Recent years have witnessed a new turn in the field of gene expression regulation. Actin and an ever-growing family of actin-associated proteins have been accepted as members of the nuclear crew, regulating eukaryotic gene transcription. In complex with heterogeneous nuclear ribonucleoproteins and certain myosin species, actin has been shown to be an important regulator in RNA polymerase II transcription. Furthermore, actin-based molecular motors are believed to facilitate RNA polymerase I transcription and possibly downstream events during rRNA biogenesis. Probably these findings represent the tip of the iceberg of a rapidly expanding area within the functional architecture of the cell nucleus. Further studies will contribute to clarify how actin mediates nuclear functions with a glance to cytoplasmic signalling. These discoveries have the potential to define novel regulatory networks required to control gene expression at multiple levels.",
keywords = "Chromatin regulation, Gene expression, Molecular motors, Nuclear actin, Nuclear myosin, Nuclear structure, rRNA biogenesis, Transcription",
author = "Emilie Louvet and Piergiorgio Percipalle",
year = "2008",
month = "12",
day = "1",
doi = "10.1016/S1937-6448(08)01603-1",
language = "English (US)",
volume = "272",
pages = "107--147",
journal = "International Review of Cell and Molecular Biology",
issn = "1937-6448",
publisher = "Elsevier Inc.",
number = "C",

}

TY - JOUR

T1 - Chapter 3 Transcriptional Control of Gene Expression by Actin and Myosin

AU - Louvet, Emilie

AU - Percipalle, Piergiorgio

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Recent years have witnessed a new turn in the field of gene expression regulation. Actin and an ever-growing family of actin-associated proteins have been accepted as members of the nuclear crew, regulating eukaryotic gene transcription. In complex with heterogeneous nuclear ribonucleoproteins and certain myosin species, actin has been shown to be an important regulator in RNA polymerase II transcription. Furthermore, actin-based molecular motors are believed to facilitate RNA polymerase I transcription and possibly downstream events during rRNA biogenesis. Probably these findings represent the tip of the iceberg of a rapidly expanding area within the functional architecture of the cell nucleus. Further studies will contribute to clarify how actin mediates nuclear functions with a glance to cytoplasmic signalling. These discoveries have the potential to define novel regulatory networks required to control gene expression at multiple levels.

AB - Recent years have witnessed a new turn in the field of gene expression regulation. Actin and an ever-growing family of actin-associated proteins have been accepted as members of the nuclear crew, regulating eukaryotic gene transcription. In complex with heterogeneous nuclear ribonucleoproteins and certain myosin species, actin has been shown to be an important regulator in RNA polymerase II transcription. Furthermore, actin-based molecular motors are believed to facilitate RNA polymerase I transcription and possibly downstream events during rRNA biogenesis. Probably these findings represent the tip of the iceberg of a rapidly expanding area within the functional architecture of the cell nucleus. Further studies will contribute to clarify how actin mediates nuclear functions with a glance to cytoplasmic signalling. These discoveries have the potential to define novel regulatory networks required to control gene expression at multiple levels.

KW - Chromatin regulation

KW - Gene expression

KW - Molecular motors

KW - Nuclear actin

KW - Nuclear myosin

KW - Nuclear structure

KW - rRNA biogenesis

KW - Transcription

UR - http://www.scopus.com/inward/record.url?scp=58049173935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58049173935&partnerID=8YFLogxK

U2 - 10.1016/S1937-6448(08)01603-1

DO - 10.1016/S1937-6448(08)01603-1

M3 - Review article

C2 - 19121817

AN - SCOPUS:58049173935

VL - 272

SP - 107

EP - 147

JO - International Review of Cell and Molecular Biology

JF - International Review of Cell and Molecular Biology

SN - 1937-6448

IS - C

ER -