Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network

Renata Batista-Brito, Gordon Fishell

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    The central goal of this manuscript is to survey our present knowledge of how cortical interneuron subtypes are generated. To achieve this, we will first define what is meant by subtype diversity. To this end, we begin by considering the mature properties that differentiate between the different populations of cortical interneurons. This requires us to address the difficulties involved in determining which characteristics allow particular interneurons to be assigned to distinct subclasses. Having grappled with this thorny issue, we will then proceed to review the progressive events in development involved in the generation of interneuron diversity. Starting with their origin and specification within the subpallium, we will follow them up through the first postnatal weeks during their integration into a functional network. Finally, we will conclude by calling the readers attention to the devastating consequences that result from developmental failures in the formation of inhibitory circuits within the cortex.

    Original languageEnglish (US)
    Title of host publicationDevelopment of Neural Circuitry
    PublisherAcademic Press Inc.
    Pages81-118
    Number of pages38
    ISBN (Print)9780123744692
    DOIs
    StatePublished - May 7 2009

    Publication series

    NameCurrent Topics in Developmental Biology
    Volume87
    ISSN (Print)0070-2153

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    Interneurons
    Population

    ASJC Scopus subject areas

    • Developmental Biology
    • Cell Biology

    Cite this

    Batista-Brito, R., & Fishell, G. (2009). Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. In Development of Neural Circuitry (pp. 81-118). (Current Topics in Developmental Biology; Vol. 87). Academic Press Inc.. https://doi.org/10.1016/S0070-2153(09)01203-4

    Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. / Batista-Brito, Renata; Fishell, Gordon.

    Development of Neural Circuitry. Academic Press Inc., 2009. p. 81-118 (Current Topics in Developmental Biology; Vol. 87).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Batista-Brito, R & Fishell, G 2009, Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. in Development of Neural Circuitry. Current Topics in Developmental Biology, vol. 87, Academic Press Inc., pp. 81-118. https://doi.org/10.1016/S0070-2153(09)01203-4
    Batista-Brito R, Fishell G. Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. In Development of Neural Circuitry. Academic Press Inc. 2009. p. 81-118. (Current Topics in Developmental Biology). https://doi.org/10.1016/S0070-2153(09)01203-4
    Batista-Brito, Renata ; Fishell, Gordon. / Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. Development of Neural Circuitry. Academic Press Inc., 2009. pp. 81-118 (Current Topics in Developmental Biology).
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