Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network

Renata Batista-Brito, Gordon Fishell

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The central goal of this manuscript is to survey our present knowledge of how cortical interneuron subtypes are generated. To achieve this, we will first define what is meant by subtype diversity. To this end, we begin by considering the mature properties that differentiate between the different populations of cortical interneurons. This requires us to address the difficulties involved in determining which characteristics allow particular interneurons to be assigned to distinct subclasses. Having grappled with this thorny issue, we will then proceed to review the progressive events in development involved in the generation of interneuron diversity. Starting with their origin and specification within the subpallium, we will follow them up through the first postnatal weeks during their integration into a functional network. Finally, we will conclude by calling the readers attention to the devastating consequences that result from developmental failures in the formation of inhibitory circuits within the cortex.

Original languageEnglish (US)
Title of host publicationDevelopment of Neural Circuitry
PublisherAcademic Press Inc.
Pages81-118
Number of pages38
ISBN (Print)9780123744692
DOIs
StatePublished - May 7 2009

Publication series

NameCurrent Topics in Developmental Biology
Volume87
ISSN (Print)0070-2153

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Interneurons
Population

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Batista-Brito, R., & Fishell, G. (2009). Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. In Development of Neural Circuitry (pp. 81-118). (Current Topics in Developmental Biology; Vol. 87). Academic Press Inc.. https://doi.org/10.1016/S0070-2153(09)01203-4

Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. / Batista-Brito, Renata; Fishell, Gordon.

Development of Neural Circuitry. Academic Press Inc., 2009. p. 81-118 (Current Topics in Developmental Biology; Vol. 87).

Research output: Chapter in Book/Report/Conference proceedingChapter

Batista-Brito, R & Fishell, G 2009, Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. in Development of Neural Circuitry. Current Topics in Developmental Biology, vol. 87, Academic Press Inc., pp. 81-118. https://doi.org/10.1016/S0070-2153(09)01203-4
Batista-Brito R, Fishell G. Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. In Development of Neural Circuitry. Academic Press Inc. 2009. p. 81-118. (Current Topics in Developmental Biology). https://doi.org/10.1016/S0070-2153(09)01203-4
Batista-Brito, Renata ; Fishell, Gordon. / Chapter 3 The Developmental Integration of Cortical Interneurons into a Functional Network. Development of Neural Circuitry. Academic Press Inc., 2009. pp. 81-118 (Current Topics in Developmental Biology).
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