Cellular and systems reconsolidation in the hippocampus

Jacek Debiec, Joseph Ledoux, Karim Nader

Research output: Contribution to journalArticle

Abstract

Cellular theories of memory consolidation posit that new memories require new protein synthesis in order to be stored. Systems consolidation theories posit that the hippocampus has a time-limited role in memory storage, after which the memory is independent of the hippocampus. Here, we show that intra-hippocampal infusions of the protein synthesis inhibitor anisomycin caused amnesia for a consolidated hippocampal-dependent contextual fear memory, but only if the memory was reactivated prior to infusion. The effect occurred even if reactivation was delayed for 45 days after training, a time when contextual memory is independent of the hippocampus. Indeed, reactivation of a hippocampus-independent memory caused the trace to again become hippocampus dependent, but only for 2 days rather than for weeks. Thus, hippocampal memories can undergo reconsolidation at both the cellular and systems levels.

Original languageEnglish (US)
Pages (from-to)527-538
Number of pages12
JournalNeuron
Volume36
Issue number3
DOIs
StatePublished - Oct 24 2002

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Hippocampus
Anisomycin
Protein Synthesis Inhibitors
Amnesia
Fear
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cellular and systems reconsolidation in the hippocampus. / Debiec, Jacek; Ledoux, Joseph; Nader, Karim.

In: Neuron, Vol. 36, No. 3, 24.10.2002, p. 527-538.

Research output: Contribution to journalArticle

Debiec, Jacek ; Ledoux, Joseph ; Nader, Karim. / Cellular and systems reconsolidation in the hippocampus. In: Neuron. 2002 ; Vol. 36, No. 3. pp. 527-538.
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