Cell therapy using an array of ultrathin hollow microneedles

Florina Silvia Iliescu, Jeremy Teo, Danilo Vrtacnik, Hayden Taylor, Ciprian Iliescu

    Research output: Contribution to journalArticle

    Abstract

    Cell transplantation traditionally employs needles to inject donor cells into tissues to treat certain diseases. However, it is difficult for the current method to achieve multiple parallel equidistant injections, which are ideal for cell therapy. This paper presents a new cell transplantation method using an array of ultrathin microneedles. The main characteristic of the needles is their high aspect ratio: each needle is 500 μm long, and has a 50 μm diameter and a very thin wall (2 μm-thick SiO2 and 1.5 μm-thick Si3N4). An array of such microneedles was successfully used to inject fluorescently labeled Mardin–Darby canine kidney cells into rat liver tissue. Viability of the cells inserted using this method was verified after 5 days. Preliminary results show that this type of microneedle array can be used for cell therapy.

    Original languageEnglish (US)
    Pages (from-to)2905-2912
    Number of pages8
    JournalMicrosystem Technologies
    Volume24
    Issue number7
    DOIs
    StatePublished - Jul 1 2018

    Fingerprint

    Needles
    hollow
    therapy
    cells
    Tissue
    needles
    transplantation
    Liver
    Rats
    Aspect ratio
    Cells
    thin walls
    kidneys
    high aspect ratio
    viability
    liver
    rats
    injection
    silicon nitride

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics
    • Hardware and Architecture
    • Electrical and Electronic Engineering

    Cite this

    Iliescu, F. S., Teo, J., Vrtacnik, D., Taylor, H., & Iliescu, C. (2018). Cell therapy using an array of ultrathin hollow microneedles. Microsystem Technologies, 24(7), 2905-2912. https://doi.org/10.1007/s00542-017-3631-2

    Cell therapy using an array of ultrathin hollow microneedles. / Iliescu, Florina Silvia; Teo, Jeremy; Vrtacnik, Danilo; Taylor, Hayden; Iliescu, Ciprian.

    In: Microsystem Technologies, Vol. 24, No. 7, 01.07.2018, p. 2905-2912.

    Research output: Contribution to journalArticle

    Iliescu, FS, Teo, J, Vrtacnik, D, Taylor, H & Iliescu, C 2018, 'Cell therapy using an array of ultrathin hollow microneedles', Microsystem Technologies, vol. 24, no. 7, pp. 2905-2912. https://doi.org/10.1007/s00542-017-3631-2
    Iliescu FS, Teo J, Vrtacnik D, Taylor H, Iliescu C. Cell therapy using an array of ultrathin hollow microneedles. Microsystem Technologies. 2018 Jul 1;24(7):2905-2912. https://doi.org/10.1007/s00542-017-3631-2
    Iliescu, Florina Silvia ; Teo, Jeremy ; Vrtacnik, Danilo ; Taylor, Hayden ; Iliescu, Ciprian. / Cell therapy using an array of ultrathin hollow microneedles. In: Microsystem Technologies. 2018 ; Vol. 24, No. 7. pp. 2905-2912.
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