Cell motility driven by actin polymerization

Alexander Mogilner, George Oster

Research output: Contribution to journalArticle

Abstract

Certain kinds of cellular movements are apparently driven by actin polymerization. Examples include the lamellipodia of spreading and migrating embryonic cells, and the bacterium Listeria monocytogenes, that propels itself through its host's cytoplasm by constructing behind it a polymerized tail of cross-linked actin filaments. Peskin et al. (1993) formulated a model to explain how a polymerizing filament could rectify the Brownian motion of an object so as to produce unidirectional force (Peskin, C., G. Odell, and G. Oster. 1993. Cellular motions and thermal fluctuations: the Brownian ratchet Biophys. J. 65:316-324). Their 'Brownian ratchet' model assumed that the filament was stiff and that thermal fluctuations affected only the 'load,' i.e., the object being pushed. However, under many conditions of biological interest, the thermal fluctuations of the load are insufficient to produce the observed motions. Here we shall show that the thermal motions of the polymerizing filaments can produce a directed force. This 'elastic Brownian ratchet' can explain quantitatively the propulsion of Listeria and the protrusive mechanics of lamellipodia. The model also explains how the polymerization process nucleates the orthogonal structure of the actin network in lamellipodia.

Original languageEnglish (US)
Pages (from-to)3030-3045
Number of pages16
JournalBiophysical Journal
Volume71
Issue number6
StatePublished - Dec 1996

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Polymerization
Pseudopodia
Cell Movement
Actins
Hot Temperature
Listeria
Listeria monocytogenes
Mechanics
Actin Cytoskeleton
Cytoplasm
Bacteria

ASJC Scopus subject areas

  • Biophysics

Cite this

Cell motility driven by actin polymerization. / Mogilner, Alexander; Oster, George.

In: Biophysical Journal, Vol. 71, No. 6, 12.1996, p. 3030-3045.

Research output: Contribution to journalArticle

Mogilner, A & Oster, G 1996, 'Cell motility driven by actin polymerization', Biophysical Journal, vol. 71, no. 6, pp. 3030-3045.
Mogilner, Alexander ; Oster, George. / Cell motility driven by actin polymerization. In: Biophysical Journal. 1996 ; Vol. 71, No. 6. pp. 3030-3045.
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