Cec-1, a soma-specific chromobox-containing gene in C. elegans

E. Agostoni, Donna Albertson, C. Wittmann, F. Hill, H. Tobler, F. Müller

Research output: Contribution to journalArticle

Abstract

The chromo domain is a phylogenetically conserved sequence motif which was identified as a region of homology between the repressor protein Pc and the heterochromatin constitutive protein HP1 of Drosophila. The specific function of the chrome domain is not yet understood, but it seems to be required for protein-protein interactions in chromatin-associated complexes. Here, we present a new chromobox-containing gene from Caenorhabditis elegans (cec-1). It encodes a nuclear protein that is present in all somatic cells from the 50- to 80-cell stage on throughout development and in adult animals. No cec-1 protein was detected in the cells of early embryos, in germ cells, and in their precursor cells Z2 and Z3. cec-1 mRNA, however, is already present in all the blastomeres of early embryos. Immunolocalization experiments revealed a homogeneous distribution of CEC-1 within interphase nuclei, while during mitosis CEC-1 seems to dissociate from the condensing chromosomes. The expression pattern of the cec-1 gene suggests that it may represent a new regulatory gene in C. elegans.

Original languageEnglish (US)
Pages (from-to)316-326
Number of pages11
JournalDevelopmental Biology
Volume178
Issue number2
DOIs
StatePublished - Sep 15 1996

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Carisoprodol
Caenorhabditis elegans
Genes
Embryonic Structures
Repressor Proteins
Blastomeres
Proteins
Heterochromatin
Conserved Sequence
Interphase
Regulator Genes
Nuclear Proteins
Mitosis
Germ Cells
Chromatin
Chromosomes
Messenger RNA

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Agostoni, E., Albertson, D., Wittmann, C., Hill, F., Tobler, H., & Müller, F. (1996). Cec-1, a soma-specific chromobox-containing gene in C. elegans. Developmental Biology, 178(2), 316-326. https://doi.org/10.1006/dbio.1996.0221

Cec-1, a soma-specific chromobox-containing gene in C. elegans. / Agostoni, E.; Albertson, Donna; Wittmann, C.; Hill, F.; Tobler, H.; Müller, F.

In: Developmental Biology, Vol. 178, No. 2, 15.09.1996, p. 316-326.

Research output: Contribution to journalArticle

Agostoni, E, Albertson, D, Wittmann, C, Hill, F, Tobler, H & Müller, F 1996, 'Cec-1, a soma-specific chromobox-containing gene in C. elegans', Developmental Biology, vol. 178, no. 2, pp. 316-326. https://doi.org/10.1006/dbio.1996.0221
Agostoni, E. ; Albertson, Donna ; Wittmann, C. ; Hill, F. ; Tobler, H. ; Müller, F. / Cec-1, a soma-specific chromobox-containing gene in C. elegans. In: Developmental Biology. 1996 ; Vol. 178, No. 2. pp. 316-326.
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