CCL2/monocyte chemoattractant protein 1 and parathyroid hormone action on bone

Jawed Akhtar Siddiqui, Nicola Partridge

Research output: Contribution to journalReview article

Abstract

Chemokines are small molecules that play a crucial role as chemoattractants for several cell types, and their components are associated with host immune responses and repair mechanisms. Chemokines selectively recruit monocytes, neutrophils, and lymphocytes and induce chemotaxis through the activation of G protein-coupled receptors. Two well-described chemokine families (CXC and CC) are known to regulate the localization and trafficking of immune cells in cases of injury, infection, and tumors. Monocyte chemoattractant protein 1 (MCP-1/CCL2) is one of the important chemokines from the CC family that controls migration and infiltration of monocytes/macrophages during inflammation. CCL2 is profoundly expressed in osteoporotic bone and prostate cancer-induced bone resorption. CCL2 also regulates physiological bone remodeling in response to hormonal and mechanical stimuli. Parathyroid hormone (PTH) has multifaceted effects on bone, depending on the mode of administration. Intermittent PTH increases bone in vivo by increasing the number and activity of osteoblasts, whereas a continuous infusion of PTH decreases bone mass by stimulating a net increase in bone resorption. CCL2 is essential for both anabolic and catabolic effects of PTH. In this review, we will discuss the pharmacological role of PTH and involvement of CCL2 in the processes of PTH-mediated bone remodeling.

Original languageEnglish (US)
Article number49
JournalFrontiers in Endocrinology
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 29 2017

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Chemokine CCL2
Parathyroid Hormone
Bone and Bones
CC Chemokines
Bone Neoplasms
Bone Remodeling
Bone Resorption
Chemokines
Monocytes
Anabolic Agents
CXC Chemokines
Chemotactic Factors
Chemotaxis
Cellular Structures
G-Protein-Coupled Receptors
Osteoblasts
Prostatic Neoplasms
Neutrophils
Macrophages
Pharmacology

Keywords

  • Chemokines
  • Monocyte chemoattractant protein 1
  • Osteoblast
  • Osteoclast
  • Parathyroid hormone and bone remodeling

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

CCL2/monocyte chemoattractant protein 1 and parathyroid hormone action on bone. / Siddiqui, Jawed Akhtar; Partridge, Nicola.

In: Frontiers in Endocrinology, Vol. 8, No. MAR, 49, 29.03.2017.

Research output: Contribution to journalReview article

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