Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes: The role of the second Cu(II) ion

Shanghao Liu, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

Two novel dinuclear Cu(II) complexes are prepared and shown to be highly active catalysis for phosphodiester transesterification. Comparative studies on the dinuclear complexes and corresponding mononuclear complexes reveal that one dinuclear complex achieves high activity by double Lewis acid and double general base catalysis while the other exploits single Lewis acid and double general base catalysis.

Original languageEnglish (US)
Pages (from-to)1779-1784
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume7
Issue number13
DOIs
StatePublished - Jul 8 1997

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Transesterification
Catalysis
Lewis Acids
Ions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Catalysis of phosphodiester transesterification by dinuclear Cu(II) complexes : The role of the second Cu(II) ion. / Liu, Shanghao; Hamilton, Andrew.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 7, No. 13, 08.07.1997, p. 1779-1784.

Research output: Contribution to journalArticle

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