Cardiovascular tissue engineering I. Perfusion bioreactors: A review

Vladimir Mironov, Vladimir A. Kasyanov, Michael J. Yost, Richard Visconti, Waleed Twal, Thomas Trusk, Xuejun Wen, Iveta Ozolanta, Arnolds Kadishs, Glenn D. Prestwich, Louis Terracio, Roger R. Markwald

Research output: Contribution to journalArticle

Abstract

Tissue engineering is a fast-evolving field of biomedical science and technology with future promise to manufacture living tissues and organs for replacement, repair, and regeneration of diseased organs. Owing to the specific role of hemodynamics in the development, maintenance, and functioning of the cardiovascular system, bioreactors are a fundamental of cardiovascular tissue engineering. The development of perfusion bioreactor technology for cardiovascular tissue engineering is a direct sequence of previous historic successes in extracorporeal circulation techniques. Bioreactors provide a fluidic environment for tissue engineered tissue and organs, and guarantee their viability, maturation, biomonitoring, testing, storage, and transportation. There are different types of bioreactors and they vary greatly in their size, complexity, and functional capabilities. Although progress in design and functional properties of perfusion bioreactors for tissue engineered blood vessels, heart valves, and myocardial patches is obvious, there are some challenges and insufficiently addressed issues, and room for bioreactor design improvement and performance optimization. These challenges include creating a triple perfusion bioreactor for vascularized tubular tissue engineered cardiac construct; designing and manufacturing fluidics-based perfused minibioreactors; incorporation of systematic mathematical modeling and computer simulation based on computational fluid dynamics into the bioreactor designing process; and development of automatic systems of hydrodynamic regime control. Designing and engineering of built-in noninvasive biomonitoring systems is another important challenge. The optimal and most efficient perfusion and conditioning regime, which accelerates tissue maturation of tissue-engineered constructs also remains to be determined. This is a first article in a series of reviews on critical elements of cardiovascular tissue engineering technology describing the current status, unsolved problems, and challenges of bioreactor technology in cardiovascular tissue engineering and outlining future trends and developments.

Original languageEnglish (US)
Pages (from-to)111-130
Number of pages20
JournalJournal of Long-Term Effects of Medical Implants
Volume16
Issue number2
StatePublished - 2006

Fingerprint

Bioreactors
Tissue Engineering
Tissue engineering
Perfusion
Tissue
Environmental Monitoring
Fluidics
Hydrodynamics
Technology
Cardiovascular system
Biomedical Technology
Extracorporeal Circulation
Engineering technology
Heart Valves
Blood vessels
Hemodynamics
Cardiovascular System
Computer Simulation
Blood Vessels
Regeneration

Keywords

  • Cardiovascular tissue engineering
  • Hydrodynamic regime
  • Noninvasive biomonitoring
  • Perfusion bioreactors

ASJC Scopus subject areas

  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine
  • Pathology and Forensic Medicine

Cite this

Mironov, V., Kasyanov, V. A., Yost, M. J., Visconti, R., Twal, W., Trusk, T., ... Markwald, R. R. (2006). Cardiovascular tissue engineering I. Perfusion bioreactors: A review. Journal of Long-Term Effects of Medical Implants, 16(2), 111-130.

Cardiovascular tissue engineering I. Perfusion bioreactors : A review. / Mironov, Vladimir; Kasyanov, Vladimir A.; Yost, Michael J.; Visconti, Richard; Twal, Waleed; Trusk, Thomas; Wen, Xuejun; Ozolanta, Iveta; Kadishs, Arnolds; Prestwich, Glenn D.; Terracio, Louis; Markwald, Roger R.

In: Journal of Long-Term Effects of Medical Implants, Vol. 16, No. 2, 2006, p. 111-130.

Research output: Contribution to journalArticle

Mironov, V, Kasyanov, VA, Yost, MJ, Visconti, R, Twal, W, Trusk, T, Wen, X, Ozolanta, I, Kadishs, A, Prestwich, GD, Terracio, L & Markwald, RR 2006, 'Cardiovascular tissue engineering I. Perfusion bioreactors: A review', Journal of Long-Term Effects of Medical Implants, vol. 16, no. 2, pp. 111-130.
Mironov V, Kasyanov VA, Yost MJ, Visconti R, Twal W, Trusk T et al. Cardiovascular tissue engineering I. Perfusion bioreactors: A review. Journal of Long-Term Effects of Medical Implants. 2006;16(2):111-130.
Mironov, Vladimir ; Kasyanov, Vladimir A. ; Yost, Michael J. ; Visconti, Richard ; Twal, Waleed ; Trusk, Thomas ; Wen, Xuejun ; Ozolanta, Iveta ; Kadishs, Arnolds ; Prestwich, Glenn D. ; Terracio, Louis ; Markwald, Roger R. / Cardiovascular tissue engineering I. Perfusion bioreactors : A review. In: Journal of Long-Term Effects of Medical Implants. 2006 ; Vol. 16, No. 2. pp. 111-130.
@article{77f13b4e35fd43eca4d91a0ea5c4d4ab,
title = "Cardiovascular tissue engineering I. Perfusion bioreactors: A review",
abstract = "Tissue engineering is a fast-evolving field of biomedical science and technology with future promise to manufacture living tissues and organs for replacement, repair, and regeneration of diseased organs. Owing to the specific role of hemodynamics in the development, maintenance, and functioning of the cardiovascular system, bioreactors are a fundamental of cardiovascular tissue engineering. The development of perfusion bioreactor technology for cardiovascular tissue engineering is a direct sequence of previous historic successes in extracorporeal circulation techniques. Bioreactors provide a fluidic environment for tissue engineered tissue and organs, and guarantee their viability, maturation, biomonitoring, testing, storage, and transportation. There are different types of bioreactors and they vary greatly in their size, complexity, and functional capabilities. Although progress in design and functional properties of perfusion bioreactors for tissue engineered blood vessels, heart valves, and myocardial patches is obvious, there are some challenges and insufficiently addressed issues, and room for bioreactor design improvement and performance optimization. These challenges include creating a triple perfusion bioreactor for vascularized tubular tissue engineered cardiac construct; designing and manufacturing fluidics-based perfused minibioreactors; incorporation of systematic mathematical modeling and computer simulation based on computational fluid dynamics into the bioreactor designing process; and development of automatic systems of hydrodynamic regime control. Designing and engineering of built-in noninvasive biomonitoring systems is another important challenge. The optimal and most efficient perfusion and conditioning regime, which accelerates tissue maturation of tissue-engineered constructs also remains to be determined. This is a first article in a series of reviews on critical elements of cardiovascular tissue engineering technology describing the current status, unsolved problems, and challenges of bioreactor technology in cardiovascular tissue engineering and outlining future trends and developments.",
keywords = "Cardiovascular tissue engineering, Hydrodynamic regime, Noninvasive biomonitoring, Perfusion bioreactors",
author = "Vladimir Mironov and Kasyanov, {Vladimir A.} and Yost, {Michael J.} and Richard Visconti and Waleed Twal and Thomas Trusk and Xuejun Wen and Iveta Ozolanta and Arnolds Kadishs and Prestwich, {Glenn D.} and Louis Terracio and Markwald, {Roger R.}",
year = "2006",
language = "English (US)",
volume = "16",
pages = "111--130",
journal = "Journal of Long-Term Effects of Medical Implants",
issn = "1050-6934",
publisher = "Begell House Inc.",
number = "2",

}

TY - JOUR

T1 - Cardiovascular tissue engineering I. Perfusion bioreactors

T2 - A review

AU - Mironov, Vladimir

AU - Kasyanov, Vladimir A.

AU - Yost, Michael J.

AU - Visconti, Richard

AU - Twal, Waleed

AU - Trusk, Thomas

AU - Wen, Xuejun

AU - Ozolanta, Iveta

AU - Kadishs, Arnolds

AU - Prestwich, Glenn D.

AU - Terracio, Louis

AU - Markwald, Roger R.

PY - 2006

Y1 - 2006

N2 - Tissue engineering is a fast-evolving field of biomedical science and technology with future promise to manufacture living tissues and organs for replacement, repair, and regeneration of diseased organs. Owing to the specific role of hemodynamics in the development, maintenance, and functioning of the cardiovascular system, bioreactors are a fundamental of cardiovascular tissue engineering. The development of perfusion bioreactor technology for cardiovascular tissue engineering is a direct sequence of previous historic successes in extracorporeal circulation techniques. Bioreactors provide a fluidic environment for tissue engineered tissue and organs, and guarantee their viability, maturation, biomonitoring, testing, storage, and transportation. There are different types of bioreactors and they vary greatly in their size, complexity, and functional capabilities. Although progress in design and functional properties of perfusion bioreactors for tissue engineered blood vessels, heart valves, and myocardial patches is obvious, there are some challenges and insufficiently addressed issues, and room for bioreactor design improvement and performance optimization. These challenges include creating a triple perfusion bioreactor for vascularized tubular tissue engineered cardiac construct; designing and manufacturing fluidics-based perfused minibioreactors; incorporation of systematic mathematical modeling and computer simulation based on computational fluid dynamics into the bioreactor designing process; and development of automatic systems of hydrodynamic regime control. Designing and engineering of built-in noninvasive biomonitoring systems is another important challenge. The optimal and most efficient perfusion and conditioning regime, which accelerates tissue maturation of tissue-engineered constructs also remains to be determined. This is a first article in a series of reviews on critical elements of cardiovascular tissue engineering technology describing the current status, unsolved problems, and challenges of bioreactor technology in cardiovascular tissue engineering and outlining future trends and developments.

AB - Tissue engineering is a fast-evolving field of biomedical science and technology with future promise to manufacture living tissues and organs for replacement, repair, and regeneration of diseased organs. Owing to the specific role of hemodynamics in the development, maintenance, and functioning of the cardiovascular system, bioreactors are a fundamental of cardiovascular tissue engineering. The development of perfusion bioreactor technology for cardiovascular tissue engineering is a direct sequence of previous historic successes in extracorporeal circulation techniques. Bioreactors provide a fluidic environment for tissue engineered tissue and organs, and guarantee their viability, maturation, biomonitoring, testing, storage, and transportation. There are different types of bioreactors and they vary greatly in their size, complexity, and functional capabilities. Although progress in design and functional properties of perfusion bioreactors for tissue engineered blood vessels, heart valves, and myocardial patches is obvious, there are some challenges and insufficiently addressed issues, and room for bioreactor design improvement and performance optimization. These challenges include creating a triple perfusion bioreactor for vascularized tubular tissue engineered cardiac construct; designing and manufacturing fluidics-based perfused minibioreactors; incorporation of systematic mathematical modeling and computer simulation based on computational fluid dynamics into the bioreactor designing process; and development of automatic systems of hydrodynamic regime control. Designing and engineering of built-in noninvasive biomonitoring systems is another important challenge. The optimal and most efficient perfusion and conditioning regime, which accelerates tissue maturation of tissue-engineered constructs also remains to be determined. This is a first article in a series of reviews on critical elements of cardiovascular tissue engineering technology describing the current status, unsolved problems, and challenges of bioreactor technology in cardiovascular tissue engineering and outlining future trends and developments.

KW - Cardiovascular tissue engineering

KW - Hydrodynamic regime

KW - Noninvasive biomonitoring

KW - Perfusion bioreactors

UR - http://www.scopus.com/inward/record.url?scp=33745043317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745043317&partnerID=8YFLogxK

M3 - Article

C2 - 16700652

AN - SCOPUS:33745043317

VL - 16

SP - 111

EP - 130

JO - Journal of Long-Term Effects of Medical Implants

JF - Journal of Long-Term Effects of Medical Implants

SN - 1050-6934

IS - 2

ER -