Cardiovascular prognosis of sustained and white-coat hypertension in patients with type 2 diabetes mellitus

Kazuo Eguchi, Satoshi Hoshide, Joji Ishikawa, Shizukiyo Ishikawa, Thomas G. Pickering, William Gerin, Gbenga Ogedegbe, Joseph E. Schwartz, Kazuyuki Shimada, Kazuomi Kario

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Cardiovascular prognosis in diabetic white-coat hypertension (WCH) has not yet been described. We designed this study to investigate the impact of WCH on cardiovascular events in patients with type 2 diabetes, compared with those having type 2 diabetes along with sustained hypertension (SH), and with nondiabetic hypertensive individuals. METHODS: We performed ambulatory blood pressure (BP) monitoring in 1207 consecutive hypertensive patients at baseline, and they were followed up for 49±22 months. The mean age was 70.7±9.8 years; 262 had type 2 diabetes; and 945 did not. They were classified as having SH with diabetes (n=210); diabetic WCH (n=52); SH alone (n=719); or WCH alone (n=226), using awake BP of 135/85 mmHg as the cutoff value. Cox regression models were used to calculate hazard ratios (HR) and 95% confidence intervals of the risk for cardiovascular events, after controlling for age, sex, body mass index, current smoking, serum creatinine, and clinical systolic BP. RESULTS: During the follow-up period, 97 cardiovascular events occurred. The incidence of cardiovascular events in the diabetic SH group was significantly higher than in the diabetic WCH, nondiabetic SH, and nondiabetic WCH (P

Original languageEnglish (US)
Pages (from-to)15-20
Number of pages6
JournalBlood Pressure Monitoring
Volume13
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

White Coat Hypertension
Type 2 Diabetes Mellitus
Hypertension
Blood Pressure
Ambulatory Blood Pressure Monitoring
Proportional Hazards Models
Creatinine
Body Mass Index
Smoking
Confidence Intervals
Incidence
Serum

Keywords

  • Ambulatory blood pressure monitoring
  • Cardiovascular events
  • Type 2 diabetes
  • White-coat hypertension

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Eguchi, K., Hoshide, S., Ishikawa, J., Ishikawa, S., Pickering, T. G., Gerin, W., ... Kario, K. (2008). Cardiovascular prognosis of sustained and white-coat hypertension in patients with type 2 diabetes mellitus. Blood Pressure Monitoring, 13(1), 15-20. https://doi.org/10.1097/MBP.0b013e3282f13f4a

Cardiovascular prognosis of sustained and white-coat hypertension in patients with type 2 diabetes mellitus. / Eguchi, Kazuo; Hoshide, Satoshi; Ishikawa, Joji; Ishikawa, Shizukiyo; Pickering, Thomas G.; Gerin, William; Ogedegbe, Gbenga; Schwartz, Joseph E.; Shimada, Kazuyuki; Kario, Kazuomi.

In: Blood Pressure Monitoring, Vol. 13, No. 1, 02.2008, p. 15-20.

Research output: Contribution to journalArticle

Eguchi, K, Hoshide, S, Ishikawa, J, Ishikawa, S, Pickering, TG, Gerin, W, Ogedegbe, G, Schwartz, JE, Shimada, K & Kario, K 2008, 'Cardiovascular prognosis of sustained and white-coat hypertension in patients with type 2 diabetes mellitus', Blood Pressure Monitoring, vol. 13, no. 1, pp. 15-20. https://doi.org/10.1097/MBP.0b013e3282f13f4a
Eguchi, Kazuo ; Hoshide, Satoshi ; Ishikawa, Joji ; Ishikawa, Shizukiyo ; Pickering, Thomas G. ; Gerin, William ; Ogedegbe, Gbenga ; Schwartz, Joseph E. ; Shimada, Kazuyuki ; Kario, Kazuomi. / Cardiovascular prognosis of sustained and white-coat hypertension in patients with type 2 diabetes mellitus. In: Blood Pressure Monitoring. 2008 ; Vol. 13, No. 1. pp. 15-20.
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