Cardiovascular Genomics

Shu Fen Wung, Kathleen T. Hickey, Jacquelyn Taylor, Matthew J. Gallek

Research output: Contribution to journalArticle

Abstract

Purpose: This article provides an update on cardiovascular genomics using three clinically relevant exemplars, including myocardial infarction (MI) and coronary artery disease (CAD), stroke, and sudden cardiac death (SCD). Organizational Construct: Recent advances in cardiovascular genomic research, testing, and clinical implications are presented. Methods: Genomic nurse experts reviewed and summarized recent salient literature to provide updates on three selected cardiovascular genomic conditions. Findings: Research is ongoing to discover comprehensive genetic markers contributing to many common forms of cardiovascular disease (CVD), including MI and stroke. However, genomic technologies are increasingly being used clinically, particularly in patients with long QT syndrome (LQTS) or hypertrophic cardiomyopathy (HCM) who are at risk for SCD. Conclusions: Currently, there are no clinically recommended genetic tests for many common forms of CVD even though direct-to-consumer genetic tests are being marketed to healthcare providers and the general public. On the other hand, genetic testing for patients with certain single gene conditions, including channelopathies (e.g., LQTS) and cardiomyopathies (e.g., HCM), is recommended clinically. Clinical Relevance: Nurses play a pivotal role in cardiogenetics and are actively engaged in direct clinical care of patients and families with a wide variety of heritable conditions. It is important for nurses to understand current development of cardiovascular genomics and be prepared to translate the new genomic knowledge into practice.

Original languageEnglish (US)
Pages (from-to)60-68
Number of pages9
JournalJournal of Nursing Scholarship
Volume45
Issue number1
DOIs
StatePublished - Mar 1 2013

Fingerprint

Genomics
Long QT Syndrome
Hypertrophic Cardiomyopathy
Sudden Cardiac Death
Nurses
Cardiovascular Diseases
Stroke
Myocardial Infarction
Channelopathies
Genetic Testing
Cardiomyopathies
Genetic Markers
Research
Health Personnel
Coronary Artery Disease
Patient Care
Technology
Genes

Keywords

  • Coronary artery disease
  • Genomics
  • Stroke
  • Sudden cardiac death

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Wung, S. F., Hickey, K. T., Taylor, J., & Gallek, M. J. (2013). Cardiovascular Genomics. Journal of Nursing Scholarship, 45(1), 60-68. https://doi.org/10.1111/jnu.12002

Cardiovascular Genomics. / Wung, Shu Fen; Hickey, Kathleen T.; Taylor, Jacquelyn; Gallek, Matthew J.

In: Journal of Nursing Scholarship, Vol. 45, No. 1, 01.03.2013, p. 60-68.

Research output: Contribution to journalArticle

Wung, SF, Hickey, KT, Taylor, J & Gallek, MJ 2013, 'Cardiovascular Genomics', Journal of Nursing Scholarship, vol. 45, no. 1, pp. 60-68. https://doi.org/10.1111/jnu.12002
Wung, Shu Fen ; Hickey, Kathleen T. ; Taylor, Jacquelyn ; Gallek, Matthew J. / Cardiovascular Genomics. In: Journal of Nursing Scholarship. 2013 ; Vol. 45, No. 1. pp. 60-68.
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