Abstract
Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses. The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections. In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca2+ activity by cannabinoids, increased viral replication and disease. This review examines the effect(s) of cannabinoids and their antagonists in viral infections.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1873-1886 |
| Number of pages | 14 |
| Journal | Pharmaceuticals |
| Volume | 3 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2010 |
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Keywords
- Immunomodulation
- Inflammation
- Pathogens
- Virus infection
ASJC Scopus subject areas
- Molecular Medicine
- Pharmaceutical Science
Cite this
Cannabinoids and viral infections. / Reiss, Carol.
In: Pharmaceuticals, Vol. 3, No. 6, 2010, p. 1873-1886.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cannabinoids and viral infections
AU - Reiss, Carol
PY - 2010
Y1 - 2010
N2 - Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses. The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections. In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca2+ activity by cannabinoids, increased viral replication and disease. This review examines the effect(s) of cannabinoids and their antagonists in viral infections.
AB - Exogenous cannabinoids or receptor antagonists may influence many cellular and systemic host responses. The anti-inflammatory activity of cannabinoids may compromise host inflammatory responses to acute viral infections, but may be beneficial in persistent infections. In neurons, where innate antiviral/pro-resolution responses include the activation of NOS-1, inhibition of Ca2+ activity by cannabinoids, increased viral replication and disease. This review examines the effect(s) of cannabinoids and their antagonists in viral infections.
KW - Immunomodulation
KW - Inflammation
KW - Pathogens
KW - Virus infection
UR - http://www.scopus.com/inward/record.url?scp=77954928704&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954928704&partnerID=8YFLogxK
U2 - 10.3390/ph3061873
DO - 10.3390/ph3061873
M3 - Article
VL - 3
SP - 1873
EP - 1886
JO - Pharmaceuticals
JF - Pharmaceuticals
SN - 1424-8247
IS - 6
ER -