Cancer targeting peptides

Mona Kalmouni, Sumaya Al-Hosani, Mazin Magzoub

    Research output: Contribution to journalReview article

    Abstract

    Despite continuing advances in the development of biomacromolecules for therapeutic purposes, successful application of these often large and hydrophilic molecules has been hindered by their inability to efficiently traverse the cellular plasma membrane. In recent years, cell-penetrating peptides (CPPs) have received considerable attention as a promising class of delivery vectors due to their ability to mediate the efficient import of a large number of cargoes in vitro and in vivo. However, the lack of target specificity of CPPs remains a major obstacle to their clinical development. To address this issue, researchers have developed strategies in which chemotherapeutic drugs are conjugated to cancer targeting peptides (CTPs) that exploit the unique characteristics of the tumor microenvironment or cancer cells, thereby improving cancer cell specificity. This review highlights several of these strategies that are currently in use, and discusses how multi-component nanoparticles conjugated to CTPs can be designed to provide a more efficient cancer therapeutic delivery strategy.

    Original languageEnglish (US)
    JournalCellular and Molecular Life Sciences
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    Peptides
    Cell-Penetrating Peptides
    Neoplasms
    Tumor Microenvironment
    Nanoparticles
    Research Personnel
    Cell Membrane
    Therapeutics
    Pharmaceutical Preparations

    Keywords

    • Hypoxia
    • Low pH
    • Metabolism
    • Nanoplatforms
    • Proteases
    • Targeted therapy
    • Tumors

    ASJC Scopus subject areas

    • Molecular Medicine
    • Molecular Biology
    • Pharmacology
    • Cellular and Molecular Neuroscience
    • Cell Biology

    Cite this

    Cancer targeting peptides. / Kalmouni, Mona; Al-Hosani, Sumaya; Magzoub, Mazin.

    In: Cellular and Molecular Life Sciences, 01.01.2019.

    Research output: Contribution to journalReview article

    Kalmouni, Mona ; Al-Hosani, Sumaya ; Magzoub, Mazin. / Cancer targeting peptides. In: Cellular and Molecular Life Sciences. 2019.
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