Can intranasal drug use reduce HCV infection among injecting drug users?

Don C. Des Jarlais, Holly Hagan, Kamyar Arasteh, Courtney McKnight, Salaam Semaan, David C. Perlman

Research output: Contribution to journalArticle

Abstract

Background: Preventing HCV infection among people who inject drugs is a difficult public health challenge. We examined the potential role of intranasal drug use in reducing HCV acquisition. Methods: Subjects were recruited from IDUs entering the Beth Israel drug detoxification program from 2005 to 2010. A structured interview was administered and serum samples were collected for HCV testing. Results: 726 active injecting drug users were recruited from 2005 to 2010. HCV prevalence was 71%, 90% reported recent heroin injection and 44% reported recent intranasal heroin use. In a multiple logistic regression analysis, being HCV seropositive was associated with more years injecting, Latino ethnicity, previous testing for HCV, and recent injection of speedball, and negatively associated with recent intranasal use of heroin (AOR = 0.52, 95% CI 0.33-0.82) and intranasal use of speedball (AOR = 0.41, 95% CI 0.31-0.80). The association between intranasal heroin use and lower HCV seroprevalance was observed among both new injectors and persons with long injecting histories (16+ years since first injection). Conclusion: Encouraging intranasal use as an alternative to injection among persons currently injecting drugs may be a viable strategy for reducing HCV transmission.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalDrug and Alcohol Dependence
Volume119
Issue number3
DOIs
StatePublished - Dec 15 2011

Fingerprint

Heroin
Drug Users
Injections
Infection
Pharmaceutical Preparations
Israel
Detoxification
Hispanic Americans
Testing
Public health
Public Health
Regression analysis
Logistic Models
Regression Analysis
Interviews
Logistics
Serum

Keywords

  • HCV
  • Injecting
  • Intranasal drug use
  • Non-injecting

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Toxicology
  • Pharmacology
  • Pharmacology (medical)

Cite this

Can intranasal drug use reduce HCV infection among injecting drug users? / Des Jarlais, Don C.; Hagan, Holly; Arasteh, Kamyar; McKnight, Courtney; Semaan, Salaam; Perlman, David C.

In: Drug and Alcohol Dependence, Vol. 119, No. 3, 15.12.2011, p. 201-206.

Research output: Contribution to journalArticle

Des Jarlais, DC, Hagan, H, Arasteh, K, McKnight, C, Semaan, S & Perlman, DC 2011, 'Can intranasal drug use reduce HCV infection among injecting drug users?', Drug and Alcohol Dependence, vol. 119, no. 3, pp. 201-206. https://doi.org/10.1016/j.drugalcdep.2011.06.020
Des Jarlais, Don C. ; Hagan, Holly ; Arasteh, Kamyar ; McKnight, Courtney ; Semaan, Salaam ; Perlman, David C. / Can intranasal drug use reduce HCV infection among injecting drug users?. In: Drug and Alcohol Dependence. 2011 ; Vol. 119, No. 3. pp. 201-206.
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