Calcitonin receptors in a cloned human breast cancer cell line (MCF 7)

T. J. Martin, D. M. Findlay, I. MacIntyre, J. A. Eisman, V. P. Michelangeli, J. M. Moseley, N. C. Partridge

Research output: Contribution to journalArticle

Abstract

A human breast cancer cell line, MCF 7, is shown to possess a specific calcitonin receptor and calcitonin responsive adenylte cyclase, and calcitonin treatment results in activation of cyclic AMP-dependent protein kinase. Studies with several analogues of calcitonin show that the receptor and adenylate cyclase response preserve the ability to discriminate among the structure function relationships of the calcitonin molecule. The same cell line has been shown recently to possess a receptor for the steroid hormone, 1,25 (OH)2-vitamin D. Coexistence in MCF 7 cells of receptors for two calcium regulating hormones may be related to the osteoclast-like properties of these cells.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume96
Issue number1
DOIs
StatePublished - 1980

Fingerprint

Calcitonin Receptors
Calcitonin
Cells
Breast Neoplasms
Cell Line
Steroid hormones
Hormones
Ergocalciferols
Calcium-Sensing Receptors
Steroid Receptors
MCF-7 Cells
Osteoclasts
Cyclic AMP-Dependent Protein Kinases
Adenylyl Cyclases
Chemical activation
Calcium
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Martin, T. J., Findlay, D. M., MacIntyre, I., Eisman, J. A., Michelangeli, V. P., Moseley, J. M., & Partridge, N. C. (1980). Calcitonin receptors in a cloned human breast cancer cell line (MCF 7). Biochemical and Biophysical Research Communications, 96(1), 150-156. https://doi.org/10.1016/0006-291X(80)91193-6

Calcitonin receptors in a cloned human breast cancer cell line (MCF 7). / Martin, T. J.; Findlay, D. M.; MacIntyre, I.; Eisman, J. A.; Michelangeli, V. P.; Moseley, J. M.; Partridge, N. C.

In: Biochemical and Biophysical Research Communications, Vol. 96, No. 1, 1980, p. 150-156.

Research output: Contribution to journalArticle

Martin, TJ, Findlay, DM, MacIntyre, I, Eisman, JA, Michelangeli, VP, Moseley, JM & Partridge, NC 1980, 'Calcitonin receptors in a cloned human breast cancer cell line (MCF 7)', Biochemical and Biophysical Research Communications, vol. 96, no. 1, pp. 150-156. https://doi.org/10.1016/0006-291X(80)91193-6
Martin, T. J. ; Findlay, D. M. ; MacIntyre, I. ; Eisman, J. A. ; Michelangeli, V. P. ; Moseley, J. M. ; Partridge, N. C. / Calcitonin receptors in a cloned human breast cancer cell line (MCF 7). In: Biochemical and Biophysical Research Communications. 1980 ; Vol. 96, No. 1. pp. 150-156.
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