C. elegans network biology: a beginning.

Fabio Piano, Kristin C. Gunsalus, David E. Hill, Marc Vidal

Research output: Contribution to journalArticle

Abstract

The architecture and dynamics of molecular networks can provide an understanding of complex biological processes complementary to that obtained from the in-depth study of single genes and proteins. With a completely sequenced and well-annotated genome, a fully characterized cell lineage, and powerful tools available to dissect development, Caenorhabditis elegans, among metazoans, provides an optimal system to bridge cellular and organismal biology with the global properties of macromolecular networks. This chapter considers omic technologies available for C. elegans to describe molecular networks--encompassing transcriptional and phenotypic profiling as well as physical interaction mapping--and discusses how their individual and integrated applications are paving the way for a network-level understanding of C. elegans biology.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalWormBook : the online review of C. elegans biology
StatePublished - 2006

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Caenorhabditis elegans
Biological Phenomena
Gene Regulatory Networks
Cell Lineage
Molecular Dynamics Simulation
Cell Biology
Genome
Technology
Proteins

ASJC Scopus subject areas

  • Medicine(all)

Cite this

C. elegans network biology : a beginning. / Piano, Fabio; Gunsalus, Kristin C.; Hill, David E.; Vidal, Marc.

In: WormBook : the online review of C. elegans biology, 2006, p. 1-20.

Research output: Contribution to journalArticle

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