Buspirone decreases the activity of 5‐hydroxytryptamine‐containing dorsal raphe neurons in‐vitro

Michael E. Trulson, Kamyar Arasteh

Research output: Contribution to journalArticle

Abstract

Buspirone, a non‐benzodiazepine anxiolytic agent, produced a dose‐dependent decrease in the activity of 5‐HT‐containing dorsal raphe neurons recorded from mouse brain slices. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects were the result of a direct action of buspirone on raphe neurons. These data are discussed within the context of the anxiolytic effects of buspirone.

Original languageEnglish (US)
Pages (from-to)380-382
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume38
Issue number5
DOIs
StatePublished - Jan 1 1986

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Buspirone
Anti-Anxiety Agents
Neurons
Magnesium
Calcium
Brain
Dorsal Raphe Nucleus

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Buspirone decreases the activity of 5‐hydroxytryptamine‐containing dorsal raphe neurons in‐vitro. / Trulson, Michael E.; Arasteh, Kamyar.

In: Journal of Pharmacy and Pharmacology, Vol. 38, No. 5, 01.01.1986, p. 380-382.

Research output: Contribution to journalArticle

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