Brief monocular deprivation leaves subthreshold synaptic input on neurones of the cat's visual cortex

C. Blakemore, Michael Hawken, R. F. Mark

Research output: Contribution to journalArticle

Abstract

We have examined neurones in area 17 of monocularly deprived kittens for subthreshold input in response to visual stimulation through the deprived eye during reversible abolition of activity from the non-deprived eye and during increased excitability of cortical neurones induced by ionophoresis of DL-homocysteic acid (DL-H). After 2 or 3 days of monocular deprivation, beginning 5 weeks post-natally, most cortical neurones were dominated by the non-deprived eye. From a sample of 43 neurones, from 3 kittens, driven exclusively by the non-deprived eye, only 16% developed responses to stimulation through the deprived eye as a result of reversible pressure blinding of the non-deprived eye. The responses through the deprived eye during pressure blinding usually developed over a period of several minutes and were always transitory: in no cases did the response persist for more than a few minutes after the return of the normal response through the non-deprived eye. Occasionally cells became responsive through the deprived eye during a short period of heightened general excitability after the release of pressure. Ionophoretic application of DL-H usually increased the spontaneous activity of cortical neurones. From 2 kittens monocularly deprived for 3 days during the 4th or 5th week of life, out of a sample of 16 cortical neurones initially responsive only through the non-deprived eye, 63% showed responses to visual stimulation through the deprived eye during DL-H application. From a kitten monocularly deprived for 12 d from post-natal day 38, 28% of 18 initially monocular neurones developed responses through the deprived eye during DL-H application. Preliminary results from intracellular recording showed apparently monocular neurones with excitatory input from the deprived eye producing subthreshold synaptic activity in response to moving bars of the same orientation that gave a suprathreshold response through the non-deprived eye.

Original languageEnglish (US)
Pages (from-to)489-505
Number of pages17
JournalJournal of Physiology
VolumeVol. 327
StatePublished - 1982

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Visual Cortex
Cats
Neurons
Photic Stimulation
Pressure

ASJC Scopus subject areas

  • Physiology

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Brief monocular deprivation leaves subthreshold synaptic input on neurones of the cat's visual cortex. / Blakemore, C.; Hawken, Michael; Mark, R. F.

In: Journal of Physiology, Vol. Vol. 327, 1982, p. 489-505.

Research output: Contribution to journalArticle

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