Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism

Yongsoo Kim, Guangyu Robert Yang, Kith Pradhan, Kannan Umadevi Venkataraju, Mihail Bota, Luis Carlos García del Molino, Greg Fitzgerald, Keerthi Ram, Miao He, Jesse Maurica Levine, Partha Mitra, Z. Josh Huang, Xiao-Jing Wang, Pavel Osten

Research output: Contribution to journalArticle

Abstract

The stereotyped features of neuronal circuits are those most likely to explain the remarkable capacity of the brain to process information and govern behaviors, yet it has not been possible to comprehensively quantify neuronal distributions across animals or genders due to the size and complexity of the mammalian brain. Here we apply our quantitative brain-wide (qBrain) mapping platform to document the stereotyped distributions of mainly inhibitory cell types. We discover an unexpected cortical organizing principle: sensory-motor areas are dominated by output-modulating parvalbumin-positive interneurons, whereas association, including frontal, areas are dominated by input-modulating somatostatin-positive interneurons. Furthermore, we identify local cell type distributions with more cells in the female brain in 10 out of 11 sexually dimorphic subcortical areas, in contrast to the overall larger brains in males. The qBrain resource can be further mined to link stereotyped aspects of neuronal distributions to known and unknown functions of diverse brain regions. A quantitative cell-type-based whole-brain anatomical resource reveals new principles of structural organization of the brain

Original languageEnglish (US)
Pages (from-to)456-469.e22
JournalCell
Volume171
Issue number2
DOIs
StatePublished - Oct 5 2017

Fingerprint

Sex Characteristics
Brain
Interneurons
Brain Mapping
Parvalbumins
Somatostatin
Animals
Networks (circuits)

Keywords

  • brain
  • Cell type
  • cortex
  • inhibition
  • sexual dimorphism

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kim, Y., Yang, G. R., Pradhan, K., Venkataraju, K. U., Bota, M., García del Molino, L. C., ... Osten, P. (2017). Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism. Cell, 171(2), 456-469.e22. https://doi.org/10.1016/j.cell.2017.09.020

Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism. / Kim, Yongsoo; Yang, Guangyu Robert; Pradhan, Kith; Venkataraju, Kannan Umadevi; Bota, Mihail; García del Molino, Luis Carlos; Fitzgerald, Greg; Ram, Keerthi; He, Miao; Levine, Jesse Maurica; Mitra, Partha; Huang, Z. Josh; Wang, Xiao-Jing; Osten, Pavel.

In: Cell, Vol. 171, No. 2, 05.10.2017, p. 456-469.e22.

Research output: Contribution to journalArticle

Kim, Y, Yang, GR, Pradhan, K, Venkataraju, KU, Bota, M, García del Molino, LC, Fitzgerald, G, Ram, K, He, M, Levine, JM, Mitra, P, Huang, ZJ, Wang, X-J & Osten, P 2017, 'Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism', Cell, vol. 171, no. 2, pp. 456-469.e22. https://doi.org/10.1016/j.cell.2017.09.020
Kim Y, Yang GR, Pradhan K, Venkataraju KU, Bota M, García del Molino LC et al. Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism. Cell. 2017 Oct 5;171(2):456-469.e22. https://doi.org/10.1016/j.cell.2017.09.020
Kim, Yongsoo ; Yang, Guangyu Robert ; Pradhan, Kith ; Venkataraju, Kannan Umadevi ; Bota, Mihail ; García del Molino, Luis Carlos ; Fitzgerald, Greg ; Ram, Keerthi ; He, Miao ; Levine, Jesse Maurica ; Mitra, Partha ; Huang, Z. Josh ; Wang, Xiao-Jing ; Osten, Pavel. / Brain-wide Maps Reveal Stereotyped Cell-Type-Based Cortical Architecture and Subcortical Sexual Dimorphism. In: Cell. 2017 ; Vol. 171, No. 2. pp. 456-469.e22.
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