Brain volume findings in 6-month-old infants at high familial risk for autism

Heather Cody Hazlett, Hongbin Gu, Robert C. McKinstry, Dennis W W Shaw, Kelly N. Botteron, Stephen R. Dager, Martin Styner, Clement Vachet, Guido Gerig, Sarah J. Paterson, Robert T. Schultz, Annette M. Estes, Alan C. Evans, Joseph Piven

    Research output: Contribution to journalArticle

    Abstract

    Objective: Individuals with autism as young as 2 years have been observed to have larger brains than healthy comparison subjects. Studies using head circumference suggest that brain enlargement is a postnatal event that occurs around the latter part of the first year. To the authors'knowledge, no previous brain imaging studies have systematically examined the period prior to age 2. In this study they used magnetic resonance imaging (MRI) to measure brain volume in 6-month-olds at high familial risk for autism. Method: The Infant Brain Imaging Study (IBIS) is a longitudinal imaging study of infants at high risk for autism. This cross-sectional analysis compared brain volumes at 6 months of age in high-risk infants (N=98) and infants without family members with autism (N=36). MRI scans were also examined for radiologic abnormalities. Results: No group differences were observed for intracranial, cerebrum, cerebellum, or lateral ventricle volume or for head circumference. Conclusions: The authors did not observe significant group differences for head circumference, brain volume, or abnormalities in radiologic findings from a group of 6-month-old infants at high risk for autism. The authors are unable to conclude that these abnormalities are not present in infants who later go on to receive a diagnosis of autism; rather, abnormalities were not detected in a large group at high familial risk. Future longitudinal studies of the IBIS study group will examine whether brain volume differs in infants who go on to develop autism.

    Original languageEnglish (US)
    Pages (from-to)601-608
    Number of pages8
    JournalAmerican Journal of Psychiatry
    Volume169
    Issue number6
    DOIs
    StatePublished - Jun 1 2012

    Fingerprint

    Autistic Disorder
    Brain
    Neuroimaging
    Head
    Longitudinal Studies
    Magnetic Resonance Imaging
    Familial
    Autism
    Lateral Ventricles
    Cerebrum
    Cerebellum
    Healthy Volunteers
    Cross-Sectional Studies
    Brain Imaging

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Arts and Humanities (miscellaneous)

    Cite this

    Hazlett, H. C., Gu, H., McKinstry, R. C., Shaw, D. W. W., Botteron, K. N., Dager, S. R., ... Piven, J. (2012). Brain volume findings in 6-month-old infants at high familial risk for autism. American Journal of Psychiatry, 169(6), 601-608. https://doi.org/10.1176/appi.ajp.2012.11091425

    Brain volume findings in 6-month-old infants at high familial risk for autism. / Hazlett, Heather Cody; Gu, Hongbin; McKinstry, Robert C.; Shaw, Dennis W W; Botteron, Kelly N.; Dager, Stephen R.; Styner, Martin; Vachet, Clement; Gerig, Guido; Paterson, Sarah J.; Schultz, Robert T.; Estes, Annette M.; Evans, Alan C.; Piven, Joseph.

    In: American Journal of Psychiatry, Vol. 169, No. 6, 01.06.2012, p. 601-608.

    Research output: Contribution to journalArticle

    Hazlett, HC, Gu, H, McKinstry, RC, Shaw, DWW, Botteron, KN, Dager, SR, Styner, M, Vachet, C, Gerig, G, Paterson, SJ, Schultz, RT, Estes, AM, Evans, AC & Piven, J 2012, 'Brain volume findings in 6-month-old infants at high familial risk for autism', American Journal of Psychiatry, vol. 169, no. 6, pp. 601-608. https://doi.org/10.1176/appi.ajp.2012.11091425
    Hazlett HC, Gu H, McKinstry RC, Shaw DWW, Botteron KN, Dager SR et al. Brain volume findings in 6-month-old infants at high familial risk for autism. American Journal of Psychiatry. 2012 Jun 1;169(6):601-608. https://doi.org/10.1176/appi.ajp.2012.11091425
    Hazlett, Heather Cody ; Gu, Hongbin ; McKinstry, Robert C. ; Shaw, Dennis W W ; Botteron, Kelly N. ; Dager, Stephen R. ; Styner, Martin ; Vachet, Clement ; Gerig, Guido ; Paterson, Sarah J. ; Schultz, Robert T. ; Estes, Annette M. ; Evans, Alan C. ; Piven, Joseph. / Brain volume findings in 6-month-old infants at high familial risk for autism. In: American Journal of Psychiatry. 2012 ; Vol. 169, No. 6. pp. 601-608.
    @article{ebe62a248ef64e4fa456be8d1bb1e406,
    title = "Brain volume findings in 6-month-old infants at high familial risk for autism",
    abstract = "Objective: Individuals with autism as young as 2 years have been observed to have larger brains than healthy comparison subjects. Studies using head circumference suggest that brain enlargement is a postnatal event that occurs around the latter part of the first year. To the authors'knowledge, no previous brain imaging studies have systematically examined the period prior to age 2. In this study they used magnetic resonance imaging (MRI) to measure brain volume in 6-month-olds at high familial risk for autism. Method: The Infant Brain Imaging Study (IBIS) is a longitudinal imaging study of infants at high risk for autism. This cross-sectional analysis compared brain volumes at 6 months of age in high-risk infants (N=98) and infants without family members with autism (N=36). MRI scans were also examined for radiologic abnormalities. Results: No group differences were observed for intracranial, cerebrum, cerebellum, or lateral ventricle volume or for head circumference. Conclusions: The authors did not observe significant group differences for head circumference, brain volume, or abnormalities in radiologic findings from a group of 6-month-old infants at high risk for autism. The authors are unable to conclude that these abnormalities are not present in infants who later go on to receive a diagnosis of autism; rather, abnormalities were not detected in a large group at high familial risk. Future longitudinal studies of the IBIS study group will examine whether brain volume differs in infants who go on to develop autism.",
    author = "Hazlett, {Heather Cody} and Hongbin Gu and McKinstry, {Robert C.} and Shaw, {Dennis W W} and Botteron, {Kelly N.} and Dager, {Stephen R.} and Martin Styner and Clement Vachet and Guido Gerig and Paterson, {Sarah J.} and Schultz, {Robert T.} and Estes, {Annette M.} and Evans, {Alan C.} and Joseph Piven",
    year = "2012",
    month = "6",
    day = "1",
    doi = "10.1176/appi.ajp.2012.11091425",
    language = "English (US)",
    volume = "169",
    pages = "601--608",
    journal = "American Journal of Psychiatry",
    issn = "0002-953X",
    publisher = "American Psychiatric Association",
    number = "6",

    }

    TY - JOUR

    T1 - Brain volume findings in 6-month-old infants at high familial risk for autism

    AU - Hazlett, Heather Cody

    AU - Gu, Hongbin

    AU - McKinstry, Robert C.

    AU - Shaw, Dennis W W

    AU - Botteron, Kelly N.

    AU - Dager, Stephen R.

    AU - Styner, Martin

    AU - Vachet, Clement

    AU - Gerig, Guido

    AU - Paterson, Sarah J.

    AU - Schultz, Robert T.

    AU - Estes, Annette M.

    AU - Evans, Alan C.

    AU - Piven, Joseph

    PY - 2012/6/1

    Y1 - 2012/6/1

    N2 - Objective: Individuals with autism as young as 2 years have been observed to have larger brains than healthy comparison subjects. Studies using head circumference suggest that brain enlargement is a postnatal event that occurs around the latter part of the first year. To the authors'knowledge, no previous brain imaging studies have systematically examined the period prior to age 2. In this study they used magnetic resonance imaging (MRI) to measure brain volume in 6-month-olds at high familial risk for autism. Method: The Infant Brain Imaging Study (IBIS) is a longitudinal imaging study of infants at high risk for autism. This cross-sectional analysis compared brain volumes at 6 months of age in high-risk infants (N=98) and infants without family members with autism (N=36). MRI scans were also examined for radiologic abnormalities. Results: No group differences were observed for intracranial, cerebrum, cerebellum, or lateral ventricle volume or for head circumference. Conclusions: The authors did not observe significant group differences for head circumference, brain volume, or abnormalities in radiologic findings from a group of 6-month-old infants at high risk for autism. The authors are unable to conclude that these abnormalities are not present in infants who later go on to receive a diagnosis of autism; rather, abnormalities were not detected in a large group at high familial risk. Future longitudinal studies of the IBIS study group will examine whether brain volume differs in infants who go on to develop autism.

    AB - Objective: Individuals with autism as young as 2 years have been observed to have larger brains than healthy comparison subjects. Studies using head circumference suggest that brain enlargement is a postnatal event that occurs around the latter part of the first year. To the authors'knowledge, no previous brain imaging studies have systematically examined the period prior to age 2. In this study they used magnetic resonance imaging (MRI) to measure brain volume in 6-month-olds at high familial risk for autism. Method: The Infant Brain Imaging Study (IBIS) is a longitudinal imaging study of infants at high risk for autism. This cross-sectional analysis compared brain volumes at 6 months of age in high-risk infants (N=98) and infants without family members with autism (N=36). MRI scans were also examined for radiologic abnormalities. Results: No group differences were observed for intracranial, cerebrum, cerebellum, or lateral ventricle volume or for head circumference. Conclusions: The authors did not observe significant group differences for head circumference, brain volume, or abnormalities in radiologic findings from a group of 6-month-old infants at high risk for autism. The authors are unable to conclude that these abnormalities are not present in infants who later go on to receive a diagnosis of autism; rather, abnormalities were not detected in a large group at high familial risk. Future longitudinal studies of the IBIS study group will examine whether brain volume differs in infants who go on to develop autism.

    UR - http://www.scopus.com/inward/record.url?scp=84862232508&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84862232508&partnerID=8YFLogxK

    U2 - 10.1176/appi.ajp.2012.11091425

    DO - 10.1176/appi.ajp.2012.11091425

    M3 - Article

    C2 - 22684595

    AN - SCOPUS:84862232508

    VL - 169

    SP - 601

    EP - 608

    JO - American Journal of Psychiatry

    JF - American Journal of Psychiatry

    SN - 0002-953X

    IS - 6

    ER -