Brain-derived neurotrophic factor: Linking fear learning to memory consolidation

Marie H. Monfils, Kiriana K. Cowansage, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays an important role in synaptic plasticity. In this issue of Molecular Pharmacology, Ou and Gean (p. 350) thoroughly describe the molecular cascade by which fear learning leads to an increase in BDNF expression in the lateral amygdala (LA). Calcium influx through N-methyl-D-aspartate receptors and L-type voltage-dependent calcium channels, which occurs in the LA during fear conditioning, activates protein kinase A and Ca2+/calmodulin- dependent protein kinase IV. Each induces phosphorylation of cAMP response element-binding protein, which binds to the BDNF promoter, leading to BDNF expression in the LA, and contributes to fear memory consolidation.

Original languageEnglish (US)
Pages (from-to)235-237
Number of pages3
JournalMolecular Pharmacology
Volume72
Issue number2
DOIs
StatePublished - Aug 2007

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Brain-Derived Neurotrophic Factor
Fear
Amygdala
Learning
Calcium-Calmodulin-Dependent Protein Kinase Type 4
Cyclic AMP Response Element-Binding Protein
L-Type Calcium Channels
Neuronal Plasticity
Nerve Growth Factors
Cyclic AMP-Dependent Protein Kinases
N-Methyl-D-Aspartate Receptors
Phosphorylation
Pharmacology
Calcium
Memory Consolidation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Brain-derived neurotrophic factor : Linking fear learning to memory consolidation. / Monfils, Marie H.; Cowansage, Kiriana K.; Ledoux, Joseph.

In: Molecular Pharmacology, Vol. 72, No. 2, 08.2007, p. 235-237.

Research output: Contribution to journalArticle

Monfils, Marie H. ; Cowansage, Kiriana K. ; Ledoux, Joseph. / Brain-derived neurotrophic factor : Linking fear learning to memory consolidation. In: Molecular Pharmacology. 2007 ; Vol. 72, No. 2. pp. 235-237.
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