Botulinum toxin management of spasmodic dysphonia (laryngeal dystonia): A 12-year experience in more than 900 patients

Andrew Blitzer, Mitchell F. Brin, Celia Stewart

Research output: Contribution to journalArticle

Abstract

Objectives: This paper reviews a 12-year experience in more than 900 patients with spasmodic dysphonia who have been treated with botulinum toxin. Study Design: This is a retrospective analysis of patients with adductor spasmodic dysphonia (strainstrangled voice), abductor spasmodic dysphonia (whispering voice), ajid adductor breathing dystonia (paradoxical vocal fold motion), all of whom have been treated with botulinum toxin injections for relief of symptom. Methods: All of the patients were studied with a complete head and neck and neurologic examination; fiberoptic laryngcstroboscopy; acoustic and aerodynamic measures; and a speech evaluation including the Universal spasmodic dysphonia rating scale. Some were given electromyography. All patients received botuilnuni toxin injections into the affected muscles under electroniyographic guidance. Results: The adductor patients had an average benefit of 90% of normal function lasting an average of 15.1 weeks. The abductor patients had an avenge benefit of 66.7% of normal function lasting an average of 10.5 weeks. Adverse effects included mild breathiness and coughing on fluids in the adductor patients, and mild stridor in a few of the abductor patients. Conclusion. Botuilnum toxin A injection of the laryngeal hyperfunctional muscles has been found over the past 12 years to be the treatment of choice to control the dystonic symptoms inmost patients with spasmodic dysphonia.

Original languageEnglish (US)
Pages (from-to)1751-1757
Number of pages7
JournalLaryngoscope
Volume125
Issue number8
DOIs
StatePublished - Aug 1 2015

Fingerprint

Dysphonia
Botulinum Toxins
Injections
Vocal Cord Dysfunction
Laryngeal Muscles
Dystonia 12
Dystonia
Respiratory Sounds
Neurologic Examination
Electromyography
Acoustics
Respiration
Neck
Head
Muscles

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Botulinum toxin management of spasmodic dysphonia (laryngeal dystonia) : A 12-year experience in more than 900 patients. / Blitzer, Andrew; Brin, Mitchell F.; Stewart, Celia.

In: Laryngoscope, Vol. 125, No. 8, 01.08.2015, p. 1751-1757.

Research output: Contribution to journalArticle

@article{afe04f7fd98743c69a7bcfaaab5c9e99,
title = "Botulinum toxin management of spasmodic dysphonia (laryngeal dystonia): A 12-year experience in more than 900 patients",
abstract = "Objectives: This paper reviews a 12-year experience in more than 900 patients with spasmodic dysphonia who have been treated with botulinum toxin. Study Design: This is a retrospective analysis of patients with adductor spasmodic dysphonia (strainstrangled voice), abductor spasmodic dysphonia (whispering voice), ajid adductor breathing dystonia (paradoxical vocal fold motion), all of whom have been treated with botulinum toxin injections for relief of symptom. Methods: All of the patients were studied with a complete head and neck and neurologic examination; fiberoptic laryngcstroboscopy; acoustic and aerodynamic measures; and a speech evaluation including the Universal spasmodic dysphonia rating scale. Some were given electromyography. All patients received botuilnuni toxin injections into the affected muscles under electroniyographic guidance. Results: The adductor patients had an average benefit of 90{\%} of normal function lasting an average of 15.1 weeks. The abductor patients had an avenge benefit of 66.7{\%} of normal function lasting an average of 10.5 weeks. Adverse effects included mild breathiness and coughing on fluids in the adductor patients, and mild stridor in a few of the abductor patients. Conclusion. Botuilnum toxin A injection of the laryngeal hyperfunctional muscles has been found over the past 12 years to be the treatment of choice to control the dystonic symptoms inmost patients with spasmodic dysphonia.",
author = "Andrew Blitzer and Brin, {Mitchell F.} and Celia Stewart",
year = "2015",
month = "8",
day = "1",
doi = "10.1002/lary.25273",
language = "English (US)",
volume = "125",
pages = "1751--1757",
journal = "Laryngoscope",
issn = "0023-852X",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Botulinum toxin management of spasmodic dysphonia (laryngeal dystonia)

T2 - A 12-year experience in more than 900 patients

AU - Blitzer, Andrew

AU - Brin, Mitchell F.

AU - Stewart, Celia

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objectives: This paper reviews a 12-year experience in more than 900 patients with spasmodic dysphonia who have been treated with botulinum toxin. Study Design: This is a retrospective analysis of patients with adductor spasmodic dysphonia (strainstrangled voice), abductor spasmodic dysphonia (whispering voice), ajid adductor breathing dystonia (paradoxical vocal fold motion), all of whom have been treated with botulinum toxin injections for relief of symptom. Methods: All of the patients were studied with a complete head and neck and neurologic examination; fiberoptic laryngcstroboscopy; acoustic and aerodynamic measures; and a speech evaluation including the Universal spasmodic dysphonia rating scale. Some were given electromyography. All patients received botuilnuni toxin injections into the affected muscles under electroniyographic guidance. Results: The adductor patients had an average benefit of 90% of normal function lasting an average of 15.1 weeks. The abductor patients had an avenge benefit of 66.7% of normal function lasting an average of 10.5 weeks. Adverse effects included mild breathiness and coughing on fluids in the adductor patients, and mild stridor in a few of the abductor patients. Conclusion. Botuilnum toxin A injection of the laryngeal hyperfunctional muscles has been found over the past 12 years to be the treatment of choice to control the dystonic symptoms inmost patients with spasmodic dysphonia.

AB - Objectives: This paper reviews a 12-year experience in more than 900 patients with spasmodic dysphonia who have been treated with botulinum toxin. Study Design: This is a retrospective analysis of patients with adductor spasmodic dysphonia (strainstrangled voice), abductor spasmodic dysphonia (whispering voice), ajid adductor breathing dystonia (paradoxical vocal fold motion), all of whom have been treated with botulinum toxin injections for relief of symptom. Methods: All of the patients were studied with a complete head and neck and neurologic examination; fiberoptic laryngcstroboscopy; acoustic and aerodynamic measures; and a speech evaluation including the Universal spasmodic dysphonia rating scale. Some were given electromyography. All patients received botuilnuni toxin injections into the affected muscles under electroniyographic guidance. Results: The adductor patients had an average benefit of 90% of normal function lasting an average of 15.1 weeks. The abductor patients had an avenge benefit of 66.7% of normal function lasting an average of 10.5 weeks. Adverse effects included mild breathiness and coughing on fluids in the adductor patients, and mild stridor in a few of the abductor patients. Conclusion. Botuilnum toxin A injection of the laryngeal hyperfunctional muscles has been found over the past 12 years to be the treatment of choice to control the dystonic symptoms inmost patients with spasmodic dysphonia.

UR - http://www.scopus.com/inward/record.url?scp=84937500666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937500666&partnerID=8YFLogxK

U2 - 10.1002/lary.25273

DO - 10.1002/lary.25273

M3 - Article

C2 - 26200329

AN - SCOPUS:84937500666

VL - 125

SP - 1751

EP - 1757

JO - Laryngoscope

JF - Laryngoscope

SN - 0023-852X

IS - 8

ER -