Boosting of neuronal firing evoked with asynchronous and synchronous inputs to the dendrite

Hysell Oviedo, Alexander Reyes

Research output: Contribution to journalArticle

Abstract

Dendritic conductances have previously been shown to boost excitatory postsynaptic potentials (EPSPs). To determine whether this boosting translates to an increase in the efficacy for evoking action potentials, we injected barrages of EPSPs that simulate the inputs generated by a population of presynaptic cells into either the dendrite or the soma of pyramidal neurons in vitro. Although the individual dendritic and somatic EPSPs were identical, barrages delivered to the dendrite generated much higher firing rates. Boosting occurred when the simulated cells fired asynchronously and synchronously. This Na+-mediated boosting, which was manifested during repetitive firing, may compensate functionally for electrotonic attenuation of EPSPs.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalNature Neuroscience
Volume5
Issue number3
DOIs
StatePublished - 2002

Fingerprint

Excitatory Postsynaptic Potentials
Dendrites
Pyramidal Cells
Carisoprodol
Action Potentials
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Boosting of neuronal firing evoked with asynchronous and synchronous inputs to the dendrite. / Oviedo, Hysell; Reyes, Alexander.

In: Nature Neuroscience, Vol. 5, No. 3, 2002, p. 261-266.

Research output: Contribution to journalArticle

@article{63385c7973754379b19d6699526cdc16,
title = "Boosting of neuronal firing evoked with asynchronous and synchronous inputs to the dendrite",
abstract = "Dendritic conductances have previously been shown to boost excitatory postsynaptic potentials (EPSPs). To determine whether this boosting translates to an increase in the efficacy for evoking action potentials, we injected barrages of EPSPs that simulate the inputs generated by a population of presynaptic cells into either the dendrite or the soma of pyramidal neurons in vitro. Although the individual dendritic and somatic EPSPs were identical, barrages delivered to the dendrite generated much higher firing rates. Boosting occurred when the simulated cells fired asynchronously and synchronously. This Na+-mediated boosting, which was manifested during repetitive firing, may compensate functionally for electrotonic attenuation of EPSPs.",
author = "Hysell Oviedo and Alexander Reyes",
year = "2002",
doi = "10.1038/nn807",
language = "English (US)",
volume = "5",
pages = "261--266",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - Boosting of neuronal firing evoked with asynchronous and synchronous inputs to the dendrite

AU - Oviedo, Hysell

AU - Reyes, Alexander

PY - 2002

Y1 - 2002

N2 - Dendritic conductances have previously been shown to boost excitatory postsynaptic potentials (EPSPs). To determine whether this boosting translates to an increase in the efficacy for evoking action potentials, we injected barrages of EPSPs that simulate the inputs generated by a population of presynaptic cells into either the dendrite or the soma of pyramidal neurons in vitro. Although the individual dendritic and somatic EPSPs were identical, barrages delivered to the dendrite generated much higher firing rates. Boosting occurred when the simulated cells fired asynchronously and synchronously. This Na+-mediated boosting, which was manifested during repetitive firing, may compensate functionally for electrotonic attenuation of EPSPs.

AB - Dendritic conductances have previously been shown to boost excitatory postsynaptic potentials (EPSPs). To determine whether this boosting translates to an increase in the efficacy for evoking action potentials, we injected barrages of EPSPs that simulate the inputs generated by a population of presynaptic cells into either the dendrite or the soma of pyramidal neurons in vitro. Although the individual dendritic and somatic EPSPs were identical, barrages delivered to the dendrite generated much higher firing rates. Boosting occurred when the simulated cells fired asynchronously and synchronously. This Na+-mediated boosting, which was manifested during repetitive firing, may compensate functionally for electrotonic attenuation of EPSPs.

UR - http://www.scopus.com/inward/record.url?scp=0036183012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036183012&partnerID=8YFLogxK

U2 - 10.1038/nn807

DO - 10.1038/nn807

M3 - Article

C2 - 11836531

AN - SCOPUS:0036183012

VL - 5

SP - 261

EP - 266

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

IS - 3

ER -