Bone regenerative potential of modified biphasic graft materials

Rehan Khan, Lukasz Witek, Matthew Breit, Dinely Colon, Nick Tovar, Malvin N. Janal, Ryo Jimbo, Paulo Coelho

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials. Materials and Methods: The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss™, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis. Results: Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks. Conclusion: Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial.

Original languageEnglish (US)
Pages (from-to)149-154
Number of pages6
JournalImplant Dentistry
Volume24
Issue number2
DOIs
StatePublished - Apr 4 2015

Fingerprint

Collagen
Transplants
Bone and Bones
Chemical Models
Osteogenesis
Skull
Polymers
Observation
polylactic acid-polyglycolic acid copolymer
Rabbits

Keywords

  • bone grafts
  • histomorphometry
  • hydroxyapatite
  • poly-lactic-co-glycolic acid
  • tricalcium phosphate

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Bone regenerative potential of modified biphasic graft materials. / Khan, Rehan; Witek, Lukasz; Breit, Matthew; Colon, Dinely; Tovar, Nick; Janal, Malvin N.; Jimbo, Ryo; Coelho, Paulo.

In: Implant Dentistry, Vol. 24, No. 2, 04.04.2015, p. 149-154.

Research output: Contribution to journalArticle

Khan, R, Witek, L, Breit, M, Colon, D, Tovar, N, Janal, MN, Jimbo, R & Coelho, P 2015, 'Bone regenerative potential of modified biphasic graft materials', Implant Dentistry, vol. 24, no. 2, pp. 149-154. https://doi.org/10.1097/ID.0000000000000220
Khan, Rehan ; Witek, Lukasz ; Breit, Matthew ; Colon, Dinely ; Tovar, Nick ; Janal, Malvin N. ; Jimbo, Ryo ; Coelho, Paulo. / Bone regenerative potential of modified biphasic graft materials. In: Implant Dentistry. 2015 ; Vol. 24, No. 2. pp. 149-154.
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