Bone mineral apposition rates at early implantation times around differently prepared titanium surfaces

a study in beagle dogs.

Paulo Coelho, Jose N. Freire, Rodrigo Granato, Charles Marin, Estevam A. Bonfante, Jose N. Gil, Sung Kiang Chuang, Marcelo Suzuki

Research output: Contribution to journalArticle

Abstract

This study evaluated the bone mineral apposition rate (MAR) at the bone-implant interface region of alumina-blasted/acid-etched (AB/AE), plasma-sprayed hydroxyapatite (PSHA), and nanometric-scale bioceramic-coated surfaces at early implantation times in a dog tibia model. Implants (n = 12 per group) with three different surfaces-AB/AE, PSHA, and a bioceramic coating in the 300- to 500-nm thickness range-were placed bilaterally along the proximal tibiae of six male beagles. Implants remained for 3 and 5 weeks in vivo. Ten and 2 days prior to euthanization, calcein green and oxytetracycline were administered for bone labeling. Following euthanization, the limbs were retrieved by sharp dissection and the implants and bone were processed nondecalcified into ~30-Μm-thick sections along the implant long axis. MAR was measured by the distance between bone labels over time at the interface region (to 0.5 mm from the implant surface) and at regions > 3 mm from the implant surface (remote site). A generalized linear mixed-effects analysis of variance model was conducted with significance levels set at .05. Irrespective of implant surface, the MAR at the interface region was significantly higher than the MAR at the remote site. Significant MAR differences in the interface region were observed between the different surfaces (PSHA > AB/AE > nano). Bone kinetics during early healing stages were influenced by implant surface modifications.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalThe International journal of oral & maxillofacial implants
Volume26
Issue number1
StatePublished - Jan 2011

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Titanium
Minerals
Dogs
Aluminum Oxide
Bone and Bones
Durapatite
Tibia
Acids
Oxytetracycline
Dissection
Analysis of Variance
Extremities

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Bone mineral apposition rates at early implantation times around differently prepared titanium surfaces : a study in beagle dogs. / Coelho, Paulo; Freire, Jose N.; Granato, Rodrigo; Marin, Charles; Bonfante, Estevam A.; Gil, Jose N.; Chuang, Sung Kiang; Suzuki, Marcelo.

In: The International journal of oral & maxillofacial implants, Vol. 26, No. 1, 01.2011, p. 63-69.

Research output: Contribution to journalArticle

Coelho, Paulo ; Freire, Jose N. ; Granato, Rodrigo ; Marin, Charles ; Bonfante, Estevam A. ; Gil, Jose N. ; Chuang, Sung Kiang ; Suzuki, Marcelo. / Bone mineral apposition rates at early implantation times around differently prepared titanium surfaces : a study in beagle dogs. In: The International journal of oral & maxillofacial implants. 2011 ; Vol. 26, No. 1. pp. 63-69.
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