Bone Homeostasis and Repair

Forced Into Shape

Alesha Castillo, Philipp Leucht

Research output: Contribution to journalArticle

Abstract

Mechanical loading is a potent anabolic regulator of bone mass, and the first line of defense for bone loss is weight-bearing exercise. Likewise, protected weight bearing is the first prescribed physical therapy following orthopedic reconstructive surgery. In both cases, enhancement of new bone formation is the goal. Our understanding of the physical cues, mechanisms of force sensation, and the subsequent cellular response will help identify novel physical and therapeutic treatments for age- and disuse-related bone loss, delayed- and nonunion fractures, and significant bony defects. This review highlights important new insights into the principles and mechanisms governing mechanical adaptation of the skeleton during homeostasis and repair and ends with a summary of clinical implications stemming from our current understanding of how bone adapts to biophysical force.

Original languageEnglish (US)
Article number58
JournalCurrent Rheumatology Reports
Volume17
Issue number9
DOIs
StatePublished - Sep 3 2015

Fingerprint

Homeostasis
Weight-Bearing
Bone and Bones
Reconstructive Surgical Procedures
Osteogenesis
Skeleton
Osteoporosis
Orthopedics
Cues
Therapeutics

Keywords

  • Bone remodeling
  • Mechanical adaptation
  • Mechanobiology
  • Osteoblast
  • Osteocyte
  • Stem cell

ASJC Scopus subject areas

  • Rheumatology

Cite this

Bone Homeostasis and Repair : Forced Into Shape. / Castillo, Alesha; Leucht, Philipp.

In: Current Rheumatology Reports, Vol. 17, No. 9, 58, 03.09.2015.

Research output: Contribution to journalArticle

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