Bluues server

Electrostatic properties of wild-type and mutated protein structures

Ian Walsh, Giovanni Minervini, Alessandra Corazza, Gennaro Esposito, Silvio C E Tosatto, Federico Fogolari

Research output: Contribution to journalArticle

Abstract

Motivation: Electrostatic calculations are an important tool for deciphering many functional mechanisms in proteins. Generalized Born (GB) models offer a fast and convenient computational approximation over other implicit solvent-based electrostatic models. Here we present a novel GB-based web server, using the program Bluues, to calculate numerous electrostatic features including pKa-values and surface potentials. The output is organized allowing both experts and beginners to rapidly sift the data. A novel feature of the Bluues server is that it explicitly allows to find electrostatic differences between wild-type and mutant structures.

Original languageEnglish (US)
Article numberbts343
Pages (from-to)2189-2190
Number of pages2
JournalBioinformatics
Volume28
Issue number16
DOIs
StatePublished - Aug 1 2012

Fingerprint

Protein Structure
Static Electricity
Electrostatics
Servers
Server
Proteins
Surface Potential
Web Server
Surface potential
Mutant
Protein
Calculate
Output
Approximation
Model

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Computational Theory and Mathematics
  • Computer Science Applications
  • Computational Mathematics
  • Statistics and Probability
  • Medicine(all)

Cite this

Walsh, I., Minervini, G., Corazza, A., Esposito, G., Tosatto, S. C. E., & Fogolari, F. (2012). Bluues server: Electrostatic properties of wild-type and mutated protein structures. Bioinformatics, 28(16), 2189-2190. [bts343]. https://doi.org/10.1093/bioinformatics/bts343

Bluues server : Electrostatic properties of wild-type and mutated protein structures. / Walsh, Ian; Minervini, Giovanni; Corazza, Alessandra; Esposito, Gennaro; Tosatto, Silvio C E; Fogolari, Federico.

In: Bioinformatics, Vol. 28, No. 16, bts343, 01.08.2012, p. 2189-2190.

Research output: Contribution to journalArticle

Walsh, I, Minervini, G, Corazza, A, Esposito, G, Tosatto, SCE & Fogolari, F 2012, 'Bluues server: Electrostatic properties of wild-type and mutated protein structures', Bioinformatics, vol. 28, no. 16, bts343, pp. 2189-2190. https://doi.org/10.1093/bioinformatics/bts343
Walsh, Ian ; Minervini, Giovanni ; Corazza, Alessandra ; Esposito, Gennaro ; Tosatto, Silvio C E ; Fogolari, Federico. / Bluues server : Electrostatic properties of wild-type and mutated protein structures. In: Bioinformatics. 2012 ; Vol. 28, No. 16. pp. 2189-2190.
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