Bluues server: Electrostatic properties of wild-type and mutated protein structures

Ian Walsh, Giovanni Minervini, Alessandra Corazza, Gennaro Esposito, Silvio C.E. Tosatto, Federico Fogolari

Research output: Contribution to journalArticle


Motivation: Electrostatic calculations are an important tool for deciphering many functional mechanisms in proteins. Generalized Born (GB) models offer a fast and convenient computational approximation over other implicit solvent-based electrostatic models. Here we present a novel GB-based web server, using the program Bluues, to calculate numerous electrostatic features including pKa-values and surface potentials. The output is organized allowing both experts and beginners to rapidly sift the data. A novel feature of the Bluues server is that it explicitly allows to find electrostatic differences between wild-type and mutant structures.

Original languageEnglish (US)
Article numberbts343
Pages (from-to)2189-2190
Number of pages2
Issue number16
StatePublished - Aug 1 2012


ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

Cite this

Walsh, I., Minervini, G., Corazza, A., Esposito, G., Tosatto, S. C. E., & Fogolari, F. (2012). Bluues server: Electrostatic properties of wild-type and mutated protein structures. Bioinformatics, 28(16), 2189-2190. [bts343].