Blood lead levels in mexico and pediatric burden of disease implications

Jack Caravanos, Russell Dowling, Martha María Téllez-Rojo, Alejandra Cantoral, Roni Kobrosly, Daniel Estrada, Manuela Orjuela, Sandra Gualtero, Bret Ericson, Anthony Rivera, Richard Fuller

Research output: Contribution to journalReview article

Abstract

Background Although there has been success in reducing lead exposure with the phase-out of leaded gasoline, exposure to lead in Mexico continues to threaten the health of millions, much of which is from lead-based glazes used in pottery that leaches into food. Objectives An extensive historical review and analysis of available data on blood lead levels in Mexican populations was conducted. We used a calculated geometric mean to evaluate the effect of lead on the pediatric burden of disease. Methods An extensive bibliographic search identified 83 published articles from 1978 to 2010 with blood lead level (BLL) data in Mexican populations representing 150 data points from more than 50,000 study participants. Values from these publications were categorized into various groupings. We then calculated the incidence of disease and disability-adjusted life-years resulting from these BLLs using the World Health Organization's burden of disease spreadsheets for mild mental retardation. Results Reviewing all relevant studies, the geometric means of Mexican BLLs in urban and rural areas were found to be 8.85 and 22.24 ug/dL, respectively. Since the phase-out of leaded gasoline, the mean in urban areas was found to be 5.36 ug/dL and the average in rural areas is expected to be much higher. The U.S. Centers for Disease Control and Prevention's (CDC) upper limit of blood lead in children under the age of 6 years is 5 ug/dL and the current U.S. average is 1.2 ug/dL. Our results indicate that more than 15% of the population will experience a decrement of more than 5 IQ points from lead exposure. The analysis also leads us to believe that lead is responsible for 820,000 disability-adjusted life-years for lead-induced mild mental retardation for children aged 0 to 4 years. Conclusion Lead continues to threaten the health of millions and remains a significant cause of disability in Mexico. Additional interventions in reducing or managing lead-based ceramic glazes are necessary to protect the public health.

Original languageEnglish (US)
Pages (from-to)269-277
Number of pages9
JournalAnnals of Global Health
Volume80
Issue number4
DOIs
StatePublished - Jul 1 2014

Fingerprint

Mexico
Pediatrics
Gasoline
Quality-Adjusted Life Years
Intellectual Disability
Population
Lead
Health
Ceramics
Centers for Disease Control and Prevention (U.S.)
Publications
Public Health
Food
Incidence

Keywords

  • blood lead level
  • burden of disease
  • children
  • DALY
  • disability-adjusted life-year
  • lead
  • Mexico
  • pottery

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Caravanos, J., Dowling, R., Téllez-Rojo, M. M., Cantoral, A., Kobrosly, R., Estrada, D., ... Fuller, R. (2014). Blood lead levels in mexico and pediatric burden of disease implications. Annals of Global Health, 80(4), 269-277. https://doi.org/10.1016/j.aogh.2014.08.002

Blood lead levels in mexico and pediatric burden of disease implications. / Caravanos, Jack; Dowling, Russell; Téllez-Rojo, Martha María; Cantoral, Alejandra; Kobrosly, Roni; Estrada, Daniel; Orjuela, Manuela; Gualtero, Sandra; Ericson, Bret; Rivera, Anthony; Fuller, Richard.

In: Annals of Global Health, Vol. 80, No. 4, 01.07.2014, p. 269-277.

Research output: Contribution to journalReview article

Caravanos, J, Dowling, R, Téllez-Rojo, MM, Cantoral, A, Kobrosly, R, Estrada, D, Orjuela, M, Gualtero, S, Ericson, B, Rivera, A & Fuller, R 2014, 'Blood lead levels in mexico and pediatric burden of disease implications', Annals of Global Health, vol. 80, no. 4, pp. 269-277. https://doi.org/10.1016/j.aogh.2014.08.002
Caravanos J, Dowling R, Téllez-Rojo MM, Cantoral A, Kobrosly R, Estrada D et al. Blood lead levels in mexico and pediatric burden of disease implications. Annals of Global Health. 2014 Jul 1;80(4):269-277. https://doi.org/10.1016/j.aogh.2014.08.002
Caravanos, Jack ; Dowling, Russell ; Téllez-Rojo, Martha María ; Cantoral, Alejandra ; Kobrosly, Roni ; Estrada, Daniel ; Orjuela, Manuela ; Gualtero, Sandra ; Ericson, Bret ; Rivera, Anthony ; Fuller, Richard. / Blood lead levels in mexico and pediatric burden of disease implications. In: Annals of Global Health. 2014 ; Vol. 80, No. 4. pp. 269-277.
@article{66728ac57a204ef49015c8dc0fc9c78a,
title = "Blood lead levels in mexico and pediatric burden of disease implications",
abstract = "Background Although there has been success in reducing lead exposure with the phase-out of leaded gasoline, exposure to lead in Mexico continues to threaten the health of millions, much of which is from lead-based glazes used in pottery that leaches into food. Objectives An extensive historical review and analysis of available data on blood lead levels in Mexican populations was conducted. We used a calculated geometric mean to evaluate the effect of lead on the pediatric burden of disease. Methods An extensive bibliographic search identified 83 published articles from 1978 to 2010 with blood lead level (BLL) data in Mexican populations representing 150 data points from more than 50,000 study participants. Values from these publications were categorized into various groupings. We then calculated the incidence of disease and disability-adjusted life-years resulting from these BLLs using the World Health Organization's burden of disease spreadsheets for mild mental retardation. Results Reviewing all relevant studies, the geometric means of Mexican BLLs in urban and rural areas were found to be 8.85 and 22.24 ug/dL, respectively. Since the phase-out of leaded gasoline, the mean in urban areas was found to be 5.36 ug/dL and the average in rural areas is expected to be much higher. The U.S. Centers for Disease Control and Prevention's (CDC) upper limit of blood lead in children under the age of 6 years is 5 ug/dL and the current U.S. average is 1.2 ug/dL. Our results indicate that more than 15{\%} of the population will experience a decrement of more than 5 IQ points from lead exposure. The analysis also leads us to believe that lead is responsible for 820,000 disability-adjusted life-years for lead-induced mild mental retardation for children aged 0 to 4 years. Conclusion Lead continues to threaten the health of millions and remains a significant cause of disability in Mexico. Additional interventions in reducing or managing lead-based ceramic glazes are necessary to protect the public health.",
keywords = "blood lead level, burden of disease, children, DALY, disability-adjusted life-year, lead, Mexico, pottery",
author = "Jack Caravanos and Russell Dowling and T{\'e}llez-Rojo, {Martha Mar{\'i}a} and Alejandra Cantoral and Roni Kobrosly and Daniel Estrada and Manuela Orjuela and Sandra Gualtero and Bret Ericson and Anthony Rivera and Richard Fuller",
year = "2014",
month = "7",
day = "1",
doi = "10.1016/j.aogh.2014.08.002",
language = "English (US)",
volume = "80",
pages = "269--277",
journal = "Annals of Global Health",
issn = "0027-2507",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Blood lead levels in mexico and pediatric burden of disease implications

AU - Caravanos, Jack

AU - Dowling, Russell

AU - Téllez-Rojo, Martha María

AU - Cantoral, Alejandra

AU - Kobrosly, Roni

AU - Estrada, Daniel

AU - Orjuela, Manuela

AU - Gualtero, Sandra

AU - Ericson, Bret

AU - Rivera, Anthony

AU - Fuller, Richard

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Background Although there has been success in reducing lead exposure with the phase-out of leaded gasoline, exposure to lead in Mexico continues to threaten the health of millions, much of which is from lead-based glazes used in pottery that leaches into food. Objectives An extensive historical review and analysis of available data on blood lead levels in Mexican populations was conducted. We used a calculated geometric mean to evaluate the effect of lead on the pediatric burden of disease. Methods An extensive bibliographic search identified 83 published articles from 1978 to 2010 with blood lead level (BLL) data in Mexican populations representing 150 data points from more than 50,000 study participants. Values from these publications were categorized into various groupings. We then calculated the incidence of disease and disability-adjusted life-years resulting from these BLLs using the World Health Organization's burden of disease spreadsheets for mild mental retardation. Results Reviewing all relevant studies, the geometric means of Mexican BLLs in urban and rural areas were found to be 8.85 and 22.24 ug/dL, respectively. Since the phase-out of leaded gasoline, the mean in urban areas was found to be 5.36 ug/dL and the average in rural areas is expected to be much higher. The U.S. Centers for Disease Control and Prevention's (CDC) upper limit of blood lead in children under the age of 6 years is 5 ug/dL and the current U.S. average is 1.2 ug/dL. Our results indicate that more than 15% of the population will experience a decrement of more than 5 IQ points from lead exposure. The analysis also leads us to believe that lead is responsible for 820,000 disability-adjusted life-years for lead-induced mild mental retardation for children aged 0 to 4 years. Conclusion Lead continues to threaten the health of millions and remains a significant cause of disability in Mexico. Additional interventions in reducing or managing lead-based ceramic glazes are necessary to protect the public health.

AB - Background Although there has been success in reducing lead exposure with the phase-out of leaded gasoline, exposure to lead in Mexico continues to threaten the health of millions, much of which is from lead-based glazes used in pottery that leaches into food. Objectives An extensive historical review and analysis of available data on blood lead levels in Mexican populations was conducted. We used a calculated geometric mean to evaluate the effect of lead on the pediatric burden of disease. Methods An extensive bibliographic search identified 83 published articles from 1978 to 2010 with blood lead level (BLL) data in Mexican populations representing 150 data points from more than 50,000 study participants. Values from these publications were categorized into various groupings. We then calculated the incidence of disease and disability-adjusted life-years resulting from these BLLs using the World Health Organization's burden of disease spreadsheets for mild mental retardation. Results Reviewing all relevant studies, the geometric means of Mexican BLLs in urban and rural areas were found to be 8.85 and 22.24 ug/dL, respectively. Since the phase-out of leaded gasoline, the mean in urban areas was found to be 5.36 ug/dL and the average in rural areas is expected to be much higher. The U.S. Centers for Disease Control and Prevention's (CDC) upper limit of blood lead in children under the age of 6 years is 5 ug/dL and the current U.S. average is 1.2 ug/dL. Our results indicate that more than 15% of the population will experience a decrement of more than 5 IQ points from lead exposure. The analysis also leads us to believe that lead is responsible for 820,000 disability-adjusted life-years for lead-induced mild mental retardation for children aged 0 to 4 years. Conclusion Lead continues to threaten the health of millions and remains a significant cause of disability in Mexico. Additional interventions in reducing or managing lead-based ceramic glazes are necessary to protect the public health.

KW - blood lead level

KW - burden of disease

KW - children

KW - DALY

KW - disability-adjusted life-year

KW - lead

KW - Mexico

KW - pottery

UR - http://www.scopus.com/inward/record.url?scp=84927607848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84927607848&partnerID=8YFLogxK

U2 - 10.1016/j.aogh.2014.08.002

DO - 10.1016/j.aogh.2014.08.002

M3 - Review article

C2 - 25459328

AN - SCOPUS:84927607848

VL - 80

SP - 269

EP - 277

JO - Annals of Global Health

JF - Annals of Global Health

SN - 0027-2507

IS - 4

ER -