Bistability requires better balanced toggle switches in the presence of competition for shared cellular resources

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Synthetic biology seeks to create complex systems in living organisms modularly. Unfortunately, modularity is hindered by several factors. One major factor limiting the scalability of rationally engineered large-scale genetic circuits is unwanted coupling among modules due to competition for shared cellular resources. Leveraging a mechanistic model explicitly accounting for the limited availability of these resources, in this paper we reveal how competition for shared resources affects the stability profile of the toggle switch, one of the most widespread genetic modules. As a result, we uncover the connection between parameter asymmetry, resource sequestration and bistability, not only in the case of a single toggle switch, but also when multiple modules all share the same pool of resources. To demonstrate the relevance of our results, we illustrate when and why the collective behavior of bistable toggle switches becomes monostable, and reveal how the interplay between parameter asymmetry and resource sequestration contributes to the emergence of this surprising phenomenon.

Original languageEnglish (US)
Title of host publication2019 American Control Conference, ACC 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1541-1546
Number of pages6
ISBN (Electronic)9781538679265
StatePublished - Jul 1 2019
Event2019 American Control Conference, ACC 2019 - Philadelphia, United States
Duration: Jul 10 2019Jul 12 2019

Publication series

NameProceedings of the American Control Conference
Volume2019-July
ISSN (Print)0743-1619

Conference

Conference2019 American Control Conference, ACC 2019
CountryUnited States
CityPhiladelphia
Period7/10/197/12/19

Fingerprint

Switches
Scalability
Large scale systems
Availability
Networks (circuits)
Synthetic Biology

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Gyorgy, A. (2019). Bistability requires better balanced toggle switches in the presence of competition for shared cellular resources. In 2019 American Control Conference, ACC 2019 (pp. 1541-1546). [8815350] (Proceedings of the American Control Conference; Vol. 2019-July). Institute of Electrical and Electronics Engineers Inc..

Bistability requires better balanced toggle switches in the presence of competition for shared cellular resources. / Gyorgy, Andras.

2019 American Control Conference, ACC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1541-1546 8815350 (Proceedings of the American Control Conference; Vol. 2019-July).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gyorgy, A 2019, Bistability requires better balanced toggle switches in the presence of competition for shared cellular resources. in 2019 American Control Conference, ACC 2019., 8815350, Proceedings of the American Control Conference, vol. 2019-July, Institute of Electrical and Electronics Engineers Inc., pp. 1541-1546, 2019 American Control Conference, ACC 2019, Philadelphia, United States, 7/10/19.
Gyorgy A. Bistability requires better balanced toggle switches in the presence of competition for shared cellular resources. In 2019 American Control Conference, ACC 2019. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1541-1546. 8815350. (Proceedings of the American Control Conference).
Gyorgy, Andras. / Bistability requires better balanced toggle switches in the presence of competition for shared cellular resources. 2019 American Control Conference, ACC 2019. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1541-1546 (Proceedings of the American Control Conference).
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