Biphenyl twist sense linkage between side-chain and main-chain conformations in a polyglutamate ester

Masahiko Sisido, Michael P. Reidy, Mark M. Green

Research output: Contribution to journalArticle

Abstract

One opportunity to test the correlation of theory and experiment in the side chain conformations of polypeptides arises from the obsevation that the biphenyl chromophore in the side chain of poly{γ-(p-phenylbenzyl)L-glutamate} (PPBLG) gives rise, in dilute solution in several solvents, to a substantial circular dichroism (CD), which is lost on denaturation of the α-helical backbone. In the work presented in this paper, the authors applied a polypeptide force field to the side chain of PPBLG in the righthanded α-helical form and discovered that the most populated side chain conformations exhibit a preference for a left handed twist about the biphenyl bond.

Original languageEnglish (US)
Pages (from-to)6860-6862
Number of pages3
JournalMacromolecules
Volume24
Issue number26
StatePublished - Jan 1 1991

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Polyglutamic Acid
Polypeptides
Conformations
Glutamic Acid
Esters
Peptides
Denaturation
Dichroism
Chromophores
Experiments
diphenyl

ASJC Scopus subject areas

  • Materials Chemistry

Cite this

Biphenyl twist sense linkage between side-chain and main-chain conformations in a polyglutamate ester. / Sisido, Masahiko; Reidy, Michael P.; Green, Mark M.

In: Macromolecules, Vol. 24, No. 26, 01.01.1991, p. 6860-6862.

Research output: Contribution to journalArticle

Sisido, Masahiko ; Reidy, Michael P. ; Green, Mark M. / Biphenyl twist sense linkage between side-chain and main-chain conformations in a polyglutamate ester. In: Macromolecules. 1991 ; Vol. 24, No. 26. pp. 6860-6862.
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