Coproporphyrinogen IV (8) is synthesised and is oxidatively decarboxylated by coproporphyrinogenase from beef-liver to produce, after aromatisation, a porphyrin proved to be protoporphyrin XIII (11) by spectroscopy and by unambiguous synthesis; the synthetic route is described. A monovinylporphyrin, derived from an intermediate for the conversion (8) → (11), is also isolated. The importance of these results for earlier biosynthetic studies with pyrromethanes is discussed.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|State||Published - Dec 1 1980|
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