Biophysical properties of dynein in vivo

George Shubeita, Babu J.N. Reddy, Steven P. Gross

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    This chapter discusses what is known about dynein function in vivo, especially with regards to biophysical properties such as force production, velocity and travel distances, and also how such functions are regulated. Dynein frequently works in ensembles, e.g. with multiple motors and co-factors working together to transport a cargo. The chapter discusses how regulation that directly targets single-molecule properties ultimately alters ensemble function.

    Original languageEnglish (US)
    Title of host publicationDyneins
    Subtitle of host publicationDynein Mechanics, Dysfunction, and Disease: Second Edition
    PublisherElsevier
    Pages136-151
    Number of pages16
    Volume2
    ISBN (Electronic)9780128097014
    ISBN (Print)9780128094709
    DOIs
    StatePublished - Nov 28 2017

    Fingerprint

    Dyneins
    Molecules

    Keywords

    • Dynactin
    • Dynein
    • Group function
    • Lis1
    • Multiple motors
    • NudE

    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    Shubeita, G., Reddy, B. J. N., & Gross, S. P. (2017). Biophysical properties of dynein in vivo. In Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second Edition (Vol. 2, pp. 136-151). Elsevier. https://doi.org/10.1016/B978-0-12-809470-9.00006-0

    Biophysical properties of dynein in vivo. / Shubeita, George; Reddy, Babu J.N.; Gross, Steven P.

    Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second Edition. Vol. 2 Elsevier, 2017. p. 136-151.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Shubeita, G, Reddy, BJN & Gross, SP 2017, Biophysical properties of dynein in vivo. in Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second Edition. vol. 2, Elsevier, pp. 136-151. https://doi.org/10.1016/B978-0-12-809470-9.00006-0
    Shubeita G, Reddy BJN, Gross SP. Biophysical properties of dynein in vivo. In Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second Edition. Vol. 2. Elsevier. 2017. p. 136-151 https://doi.org/10.1016/B978-0-12-809470-9.00006-0
    Shubeita, George ; Reddy, Babu J.N. ; Gross, Steven P. / Biophysical properties of dynein in vivo. Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second Edition. Vol. 2 Elsevier, 2017. pp. 136-151
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