Biomechanical and histomorphometric evaluation of a thin ion beam bioceramic deposition on plateau root form implants: An experimental study in dogs

Rodrigo Granato, Charles Marin, Marcelo Suzuki, Jose N. Gil, Malvin N. Janal, Paulo Coelho

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the biomechanical fixation, bone-to-implant contact, and bone morphology of an ion beam assisted deposition of a 300-500 nm thick Ca-and P-based bioceramic surface on a previously alumina-blasted/acid-etched Ti-6Al-4V implant surface in a dog model. Materials and Methods: Thirty-six 4.5 × 11 mm plateau root form implants, control (alumina-blasted/acid-etched-AB/AE) and test groups (AB/AE+300-500 nm bioceramic coating, Nanotite™) were placed along a proximal tibia of six beagle dogs remaining for 2 and 4 weeks (n = 3 animals per implantation time). Following euthanization, the implants were torqued to interface fracture at ∼0.196 radians/sec until a 10% maximum load drop was detected. The implants in bone were nondecalcified processed to ∼30 μm thickness slides for histomorphologic and bone-to-implant contact (BIC) assessment. Statistical analyses for torque to interface fracture were performed using a mixed model ANOVA, and BIC was evaluated by the χ2 test at 95% level of significance. Results: At 4 weeks, significantly higher torque to interface fracture was observed for the Test implant surface. Histomorphologic analysis showed higher degrees of bone organization for test implants compared to control at 2 and 4 weeks. Significantly higher BIC was observed at 4 weeks compared to 2 weeks (no statistical differences between control and test implants). Conclusion: The higher torque to interface fracture and increased bone maturity obtained in this study support that the surface modification comprising a 300-500 nm Ca- and P-based bioceramic coating positively influenced healing around pleateau root form implants.

Original languageEnglish (US)
Pages (from-to)396-403
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume90
Issue number1
DOIs
StatePublished - 2009

Fingerprint

Bioceramics
Ion beams
Bone
Torque
Aluminum Oxide
Alumina
Ion beam assisted deposition
Coatings
Acids
Analysis of variance (ANOVA)
Surface treatment
Animals

Keywords

  • Dental implant
  • Dogs
  • Implant surface
  • Thin coating

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Biomechanical and histomorphometric evaluation of a thin ion beam bioceramic deposition on plateau root form implants : An experimental study in dogs. / Granato, Rodrigo; Marin, Charles; Suzuki, Marcelo; Gil, Jose N.; Janal, Malvin N.; Coelho, Paulo.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 90, No. 1, 2009, p. 396-403.

Research output: Contribution to journalArticle

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title = "Biomechanical and histomorphometric evaluation of a thin ion beam bioceramic deposition on plateau root form implants: An experimental study in dogs",
abstract = "The aim of this study was to evaluate the biomechanical fixation, bone-to-implant contact, and bone morphology of an ion beam assisted deposition of a 300-500 nm thick Ca-and P-based bioceramic surface on a previously alumina-blasted/acid-etched Ti-6Al-4V implant surface in a dog model. Materials and Methods: Thirty-six 4.5 × 11 mm plateau root form implants, control (alumina-blasted/acid-etched-AB/AE) and test groups (AB/AE+300-500 nm bioceramic coating, Nanotite™) were placed along a proximal tibia of six beagle dogs remaining for 2 and 4 weeks (n = 3 animals per implantation time). Following euthanization, the implants were torqued to interface fracture at ∼0.196 radians/sec until a 10{\%} maximum load drop was detected. The implants in bone were nondecalcified processed to ∼30 μm thickness slides for histomorphologic and bone-to-implant contact (BIC) assessment. Statistical analyses for torque to interface fracture were performed using a mixed model ANOVA, and BIC was evaluated by the χ2 test at 95{\%} level of significance. Results: At 4 weeks, significantly higher torque to interface fracture was observed for the Test implant surface. Histomorphologic analysis showed higher degrees of bone organization for test implants compared to control at 2 and 4 weeks. Significantly higher BIC was observed at 4 weeks compared to 2 weeks (no statistical differences between control and test implants). Conclusion: The higher torque to interface fracture and increased bone maturity obtained in this study support that the surface modification comprising a 300-500 nm Ca- and P-based bioceramic coating positively influenced healing around pleateau root form implants.",
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