Biochemical mechanisms for translational regulation in synaptic plasticity

Eric Klann, Thomas E. Dever

Research output: Contribution to journalArticle

Abstract

Changes in gene expression are required for long-lasting synaptic plasticity and long-term memory in both invertebrates and vertebrates. Regulation of local protein synthesis allows synapses to control synaptic strength independently of messenger RNA synthesis in the cell body. Recent reports indicate that several biochemical signalling cascades couple neurotransmitter and neurotrophin receptors to translational regulatory factors in protein synthesis-dependent forms of synaptic plasticity and memory. In this review, we highlight these translational regulatory mechanisms and the signalling pathways that govern the expression of synaptic plasticity in response to specific types of neuronal stimulation.

Original languageEnglish (US)
Pages (from-to)931-942
Number of pages12
JournalNature Reviews Neuroscience
Volume5
Issue number12
DOIs
StatePublished - Dec 2004

Fingerprint

Neuronal Plasticity
Nerve Growth Factor Receptors
Neurotransmitter Receptor
Long-Term Memory
Invertebrates
Synapses
Vertebrates
Proteins
Gene Expression
Messenger RNA

ASJC Scopus subject areas

  • Cell Biology
  • Neuroscience(all)

Cite this

Biochemical mechanisms for translational regulation in synaptic plasticity. / Klann, Eric; Dever, Thomas E.

In: Nature Reviews Neuroscience, Vol. 5, No. 12, 12.2004, p. 931-942.

Research output: Contribution to journalArticle

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