Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering

Anjali Tripathi, Sekaran Saravanan, Soumitri Pattnaik, Ambigapathi Moorthi, Nicola Partridge, Nagarajan Selvamurugan

Research output: Contribution to journalArticle

Abstract

The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering.

Original languageEnglish (US)
Pages (from-to)294-299
Number of pages6
JournalInternational Journal of Biological Macromolecules
Volume50
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Chitosan
Durapatite
Tissue Engineering
Tissue engineering
Scaffolds
Zinc
Copper
Bone
Nanoparticles
Bone and Bones
Composite materials
Freeze Drying
Scaffolds (biology)
Proteolysis
Adsorption
Toxicity
Swelling
Rats
Energy dispersive spectroscopy
Drying

Keywords

  • Antibacterial activity
  • Bone
  • Chitosan
  • Copper-zinc alloy
  • Cytotoxicity
  • Nano-hydroxyapatite

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Cite this

Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering. / Tripathi, Anjali; Saravanan, Sekaran; Pattnaik, Soumitri; Moorthi, Ambigapathi; Partridge, Nicola; Selvamurugan, Nagarajan.

In: International Journal of Biological Macromolecules, Vol. 50, No. 1, 01.01.2012, p. 294-299.

Research output: Contribution to journalArticle

Tripathi, Anjali ; Saravanan, Sekaran ; Pattnaik, Soumitri ; Moorthi, Ambigapathi ; Partridge, Nicola ; Selvamurugan, Nagarajan. / Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering. In: International Journal of Biological Macromolecules. 2012 ; Vol. 50, No. 1. pp. 294-299.
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