Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter

Jia Ling, Kristaley Yui Umezawa, Theresa Scott, Stephen Small

Research output: Contribution to journalArticle

Abstract

Ling et al. identify a two-motif sequence code that is required and sufficient for activation of a specific promoter by the transcription factor Bicoid. They suggest that binding a single factor to both enhancers and promoters increases the probability that they will interact.

Original languageEnglish (US)
Pages (from-to)1178-1187.e4
JournalMolecular Cell
Volume75
Issue number6
DOIs
StatePublished - Sep 19 2019

Keywords

  • enhancer
  • gene regulation
  • promoter
  • promoter choice
  • transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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