Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter

Jia Ling, Kristaley Yui Umezawa, Theresa Scott, Stephen Small

Research output: Contribution to journalArticle

Abstract

Ling et al. identify a two-motif sequence code that is required and sufficient for activation of a specific promoter by the transcription factor Bicoid. They suggest that binding a single factor to both enhancers and promoters increases the probability that they will interact.

Original languageEnglish (US)
Pages (from-to)1178-1187.e4
JournalMolecular Cell
Volume75
Issue number6
DOIs
StatePublished - Sep 19 2019

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Transcriptional Activation
Transcription Factors

Keywords

  • enhancer
  • gene regulation
  • promoter
  • promoter choice
  • transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter. / Ling, Jia; Umezawa, Kristaley Yui; Scott, Theresa; Small, Stephen.

In: Molecular Cell, Vol. 75, No. 6, 19.09.2019, p. 1178-1187.e4.

Research output: Contribution to journalArticle

Ling, Jia ; Umezawa, Kristaley Yui ; Scott, Theresa ; Small, Stephen. / Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter. In: Molecular Cell. 2019 ; Vol. 75, No. 6. pp. 1178-1187.e4.
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