Beta-adrenergic blockade at memory encoding, but not retrieval, decreases the subjective sense of recollection

Ulrike Rimmele, Sandra F. Lackovic, Russell H. Tobe, Bennett L. Leventhal, Elizabeth Phelps

Research output: Contribution to journalArticle

Abstract

Humans remember emotional events not only better but also exhibit a qualitatively distinct recollective experience—that is, emotion intensifies the subjective vividness of the memory, the sense of reliving the event, and confidence in the accuracy of the memory [Phelps, E. A., & Sharot, T. How (and why) emotion enhances the subjective sense of recollection. Current Directions in Psychological Science, 17, 147–152, 2008]. Although it has been demonstrated that activation of the betaadrenergic system, linked to increases in stress hormone levels and physiological arousal, mediates enhanced emotional memory accuracy, the mechanism underlying the increased subjective sense of recollection is unknown. Behavioral evidence suggests that increased arousal associated with emotional events, either at encoding or retrieval, underlies their increased subjective sense of recollection. Using a double-blind, placebo-controlled, withinsubject design, we showed that reducing arousal at encoding through oral intake of 80-mg of the beta-adrenergic receptor antagonist propranolol decreases the subjective sense of recollection for both negative and neutral stimuli 24 hr later. In contrast, administration of propranolol before memory retrieval did not alter the subjective sense of recollection. These results suggest that the neurohormonal changes underlying increased arousal at the time ofmemory formation, rather than the time of memory retrieval, modulate the subjective sense of recollection.

Original languageEnglish (US)
Pages (from-to)895-907
Number of pages13
JournalJournal of Cognitive Neuroscience
Volume28
Issue number6
DOIs
StatePublished - Jun 1 2016

Fingerprint

Adrenergic Agents
Arousal
Propranolol
event
Emotions
emotion
Adrenergic Antagonists
Receptors, Adrenergic, beta
activation
stimulus
confidence
Placebos
Recollection
Encoding
Hormones
Psychology
Emotion
science
evidence
time

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Language and Linguistics
  • Linguistics and Language

Cite this

Beta-adrenergic blockade at memory encoding, but not retrieval, decreases the subjective sense of recollection. / Rimmele, Ulrike; Lackovic, Sandra F.; Tobe, Russell H.; Leventhal, Bennett L.; Phelps, Elizabeth.

In: Journal of Cognitive Neuroscience, Vol. 28, No. 6, 01.06.2016, p. 895-907.

Research output: Contribution to journalArticle

Rimmele, Ulrike ; Lackovic, Sandra F. ; Tobe, Russell H. ; Leventhal, Bennett L. ; Phelps, Elizabeth. / Beta-adrenergic blockade at memory encoding, but not retrieval, decreases the subjective sense of recollection. In: Journal of Cognitive Neuroscience. 2016 ; Vol. 28, No. 6. pp. 895-907.
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