Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort

G. Brucato, M. D. Masucci, L. Y. Arndt, S. Ben-David, T. Colibazzi, C. M. Corcoran, A. H. Crumbley, F. M. Crump, K. E. Gill, D. Kimhy, A. Lister, S. A. Schobel, Larry Yang, J. A. Lieberman, R. R. Girgis

Research output: Contribution to journalArticle

Abstract

Background: DSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria. Method: We prospectively studied 200 participants meeting criteria for both the SIPS APSS and DSM-5 APS. SIPS scores, demographics, family history of psychosis, DSM Axis-I diagnoses, schizotypy, and social and role functioning were assessed at baseline, with follow-up every 3 months for 2 years. Results: The conversion rate was 30% (n = 60), or 37.7% excluding participants who were followed under 2 years. This rate was stable across time. Conversion time averaged 7.97 months for 60% who developed schizophrenia and 15.68 for other psychoses. Mean conversion age was 20.3 for males and 23.5 for females. Attenuated odd ideas and thought disorder appear to be the positive symptoms which best predict psychosis in a logistic regression. Total negative symptom score, Asian/Pacific Islander and Black/African-American race were also predictive. As no Axis-I diagnosis or schizotypy predicted conversion, the APS is supported as a distinct syndrome. In addition, cannabis use disorder did not increase risk of conversion to psychosis. Conclusions: NAPLS SIPS findings were replicated while controlling for clinical and demographic factors, strongly supporting the validity of the SIPS APSS and DSM-5 APS diagnosis.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalPsychological Medicine
DOIs
StateAccepted/In press - Mar 2 2017

Fingerprint

Psychotic Disorders
Demography
Interviews
Cannabis
African Americans
Schizophrenia
Logistic Models

Keywords

  • Attenuated psychosis
  • clinical high-risk for psychosis
  • first episode of psychosis
  • prodromal psychosis
  • schizotypy

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Brucato, G., Masucci, M. D., Arndt, L. Y., Ben-David, S., Colibazzi, T., Corcoran, C. M., ... Girgis, R. R. (Accepted/In press). Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort. Psychological Medicine, 1-13. https://doi.org/10.1017/S0033291717000319

Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort. / Brucato, G.; Masucci, M. D.; Arndt, L. Y.; Ben-David, S.; Colibazzi, T.; Corcoran, C. M.; Crumbley, A. H.; Crump, F. M.; Gill, K. E.; Kimhy, D.; Lister, A.; Schobel, S. A.; Yang, Larry; Lieberman, J. A.; Girgis, R. R.

In: Psychological Medicine, 02.03.2017, p. 1-13.

Research output: Contribution to journalArticle

Brucato, G, Masucci, MD, Arndt, LY, Ben-David, S, Colibazzi, T, Corcoran, CM, Crumbley, AH, Crump, FM, Gill, KE, Kimhy, D, Lister, A, Schobel, SA, Yang, L, Lieberman, JA & Girgis, RR 2017, 'Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort', Psychological Medicine, pp. 1-13. https://doi.org/10.1017/S0033291717000319
Brucato, G. ; Masucci, M. D. ; Arndt, L. Y. ; Ben-David, S. ; Colibazzi, T. ; Corcoran, C. M. ; Crumbley, A. H. ; Crump, F. M. ; Gill, K. E. ; Kimhy, D. ; Lister, A. ; Schobel, S. A. ; Yang, Larry ; Lieberman, J. A. ; Girgis, R. R. / Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort. In: Psychological Medicine. 2017 ; pp. 1-13.
@article{28ed09d2a13a4c2c9b655a276f0401c3,
title = "Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort",
abstract = "Background: DSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria. Method: We prospectively studied 200 participants meeting criteria for both the SIPS APSS and DSM-5 APS. SIPS scores, demographics, family history of psychosis, DSM Axis-I diagnoses, schizotypy, and social and role functioning were assessed at baseline, with follow-up every 3 months for 2 years. Results: The conversion rate was 30{\%} (n = 60), or 37.7{\%} excluding participants who were followed under 2 years. This rate was stable across time. Conversion time averaged 7.97 months for 60{\%} who developed schizophrenia and 15.68 for other psychoses. Mean conversion age was 20.3 for males and 23.5 for females. Attenuated odd ideas and thought disorder appear to be the positive symptoms which best predict psychosis in a logistic regression. Total negative symptom score, Asian/Pacific Islander and Black/African-American race were also predictive. As no Axis-I diagnosis or schizotypy predicted conversion, the APS is supported as a distinct syndrome. In addition, cannabis use disorder did not increase risk of conversion to psychosis. Conclusions: NAPLS SIPS findings were replicated while controlling for clinical and demographic factors, strongly supporting the validity of the SIPS APSS and DSM-5 APS diagnosis.",
keywords = "Attenuated psychosis, clinical high-risk for psychosis, first episode of psychosis, prodromal psychosis, schizotypy",
author = "G. Brucato and Masucci, {M. D.} and Arndt, {L. Y.} and S. Ben-David and T. Colibazzi and Corcoran, {C. M.} and Crumbley, {A. H.} and Crump, {F. M.} and Gill, {K. E.} and D. Kimhy and A. Lister and Schobel, {S. A.} and Larry Yang and Lieberman, {J. A.} and Girgis, {R. R.}",
year = "2017",
month = "3",
day = "2",
doi = "10.1017/S0033291717000319",
language = "English (US)",
pages = "1--13",
journal = "Psychological Medicine",
issn = "0033-2917",
publisher = "Cambridge University Press",

}

TY - JOUR

T1 - Baseline demographics, clinical features and predictors of conversion among 200 individuals in a longitudinal prospective psychosis-risk cohort

AU - Brucato, G.

AU - Masucci, M. D.

AU - Arndt, L. Y.

AU - Ben-David, S.

AU - Colibazzi, T.

AU - Corcoran, C. M.

AU - Crumbley, A. H.

AU - Crump, F. M.

AU - Gill, K. E.

AU - Kimhy, D.

AU - Lister, A.

AU - Schobel, S. A.

AU - Yang, Larry

AU - Lieberman, J. A.

AU - Girgis, R. R.

PY - 2017/3/2

Y1 - 2017/3/2

N2 - Background: DSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria. Method: We prospectively studied 200 participants meeting criteria for both the SIPS APSS and DSM-5 APS. SIPS scores, demographics, family history of psychosis, DSM Axis-I diagnoses, schizotypy, and social and role functioning were assessed at baseline, with follow-up every 3 months for 2 years. Results: The conversion rate was 30% (n = 60), or 37.7% excluding participants who were followed under 2 years. This rate was stable across time. Conversion time averaged 7.97 months for 60% who developed schizophrenia and 15.68 for other psychoses. Mean conversion age was 20.3 for males and 23.5 for females. Attenuated odd ideas and thought disorder appear to be the positive symptoms which best predict psychosis in a logistic regression. Total negative symptom score, Asian/Pacific Islander and Black/African-American race were also predictive. As no Axis-I diagnosis or schizotypy predicted conversion, the APS is supported as a distinct syndrome. In addition, cannabis use disorder did not increase risk of conversion to psychosis. Conclusions: NAPLS SIPS findings were replicated while controlling for clinical and demographic factors, strongly supporting the validity of the SIPS APSS and DSM-5 APS diagnosis.

AB - Background: DSM-5 proposes an Attenuated Psychosis Syndrome (APS) for further investigation, based upon the Attenuated Positive Symptom Syndrome (APSS) in the Structured Interview for Psychosis-Risk Syndromes (SIPS). SIPS Unusual Thought Content, Disorganized Communication and Total Disorganization scores predicted progression to psychosis in a 2015 NAPLS-2 Consortium report. We sought to independently replicate this in a large single-site high-risk cohort, and identify baseline demographic and clinical predictors beyond current APS/APSS criteria. Method: We prospectively studied 200 participants meeting criteria for both the SIPS APSS and DSM-5 APS. SIPS scores, demographics, family history of psychosis, DSM Axis-I diagnoses, schizotypy, and social and role functioning were assessed at baseline, with follow-up every 3 months for 2 years. Results: The conversion rate was 30% (n = 60), or 37.7% excluding participants who were followed under 2 years. This rate was stable across time. Conversion time averaged 7.97 months for 60% who developed schizophrenia and 15.68 for other psychoses. Mean conversion age was 20.3 for males and 23.5 for females. Attenuated odd ideas and thought disorder appear to be the positive symptoms which best predict psychosis in a logistic regression. Total negative symptom score, Asian/Pacific Islander and Black/African-American race were also predictive. As no Axis-I diagnosis or schizotypy predicted conversion, the APS is supported as a distinct syndrome. In addition, cannabis use disorder did not increase risk of conversion to psychosis. Conclusions: NAPLS SIPS findings were replicated while controlling for clinical and demographic factors, strongly supporting the validity of the SIPS APSS and DSM-5 APS diagnosis.

KW - Attenuated psychosis

KW - clinical high-risk for psychosis

KW - first episode of psychosis

KW - prodromal psychosis

KW - schizotypy

UR - http://www.scopus.com/inward/record.url?scp=85014061618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014061618&partnerID=8YFLogxK

U2 - 10.1017/S0033291717000319

DO - 10.1017/S0033291717000319

M3 - Article

SP - 1

EP - 13

JO - Psychological Medicine

JF - Psychological Medicine

SN - 0033-2917

ER -