Balance of Activity between LNvs and Glutamatergic Dorsal Clock Neurons Promotes Robust Circadian Rhythms in Drosophila

Ben Collins, Elizabeth A. Kane, David C. Reeves, Myles H. Akabas, Justin Blau

Research output: Contribution to journalArticle

Abstract

Circadian rhythms offer an excellent opportunity to dissect the neural circuits underlying innate behavior because the genes and neurons involved are relatively well understood. We first sought to understand how Drosophila clock neurons interact in the simple circuit that generates circadian rhythms in larval light avoidance. We used genetics to manipulate two groups of clock neurons, increasing or reducing excitability, stopping their molecular clocks, and blocking neurotransmitter release and reception. Our results revealed that lateral neurons (LNvs) promote and dorsal clock neurons (DN1s) inhibit light avoidance, these neurons probably signal at different times of day, and both signals are required for rhythmic behavior. We found that similar principles apply in the more complex adult circadian circuit that generates locomotor rhythms. Thus, the changing balance in activity between clock neurons with opposing behavioral effects generates robust circadian behavior and probably helps organisms transition between discrete behavioral states, such as sleep and wakefulness.

Original languageEnglish (US)
Pages (from-to)706-718
Number of pages13
JournalNeuron
Volume74
Issue number4
DOIs
StatePublished - May 24 2012

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Circadian Rhythm
Drosophila
Neurons
Instinct
Light
Wakefulness
Neurotransmitter Agents
Sleep
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

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Balance of Activity between LNvs and Glutamatergic Dorsal Clock Neurons Promotes Robust Circadian Rhythms in Drosophila. / Collins, Ben; Kane, Elizabeth A.; Reeves, David C.; Akabas, Myles H.; Blau, Justin.

In: Neuron, Vol. 74, No. 4, 24.05.2012, p. 706-718.

Research output: Contribution to journalArticle

Collins, Ben ; Kane, Elizabeth A. ; Reeves, David C. ; Akabas, Myles H. ; Blau, Justin. / Balance of Activity between LNvs and Glutamatergic Dorsal Clock Neurons Promotes Robust Circadian Rhythms in Drosophila. In: Neuron. 2012 ; Vol. 74, No. 4. pp. 706-718.
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