Automated detection of chromosome aberration using color information

Chung Ho Chen, Yao Wang, Sanjit K. Mitra, Joe W. Gray

Research output: Contribution to journalArticle

Abstract

An automated scheme for the detection of chromosome aberrations in color chromosome images is described. The analysis scheme consists of three steps: segmentation, clustering, and scene understanding. First the target chromosome pixels are segmented via thresholding based on a chosen color measure. Then a clustering technique is applied to cluster the target chromosome pixels into groups in such a way that every group corresponds to a unique target chromosome domain. Finally, human chromosome aberrations are detected by calculating the geometrical properties of each detected group and counting the number of the confirmed target chromosomes. Experiments have been carried out to compare the effectiveness of several color measures for the purpose of the segmentation. Moreover, a novel self-tuning thresholding method has been developed to improve the robustness of segmentation. With this method, chromosome aberrations can be idetified even under different background brightness and chrominance distribution.

Original languageEnglish (US)
Pages (from-to)339-343
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume1192
DOIs
StatePublished - Mar 1 1990

Fingerprint

chromosome aberrations
chromosomes
Chromosomes
Aberrations
Aberration
Chromosome
Color
color
Target
pixels
Segmentation
Thresholding
brightness distribution
Pixel
Pixels
Clustering
counting
Self-tuning
tuning
Brightness

ASJC Scopus subject areas

  • Applied Mathematics
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Electrical and Electronic Engineering
  • Computer Science Applications

Cite this

Automated detection of chromosome aberration using color information. / Chen, Chung Ho; Wang, Yao; Mitra, Sanjit K.; Gray, Joe W.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 1192, 01.03.1990, p. 339-343.

Research output: Contribution to journalArticle

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