Attention stabilizes the shared gain of V4 populations

Neil C. Rabinowitz, Robbe L. Goris, Marlene Cohen, Eero Simoncelli

Research output: Contribution to journalArticle

Abstract

Responses of sensory neurons represent stimulus information, but are also influenced by internal state. For example, when monkeys direct their attention to a visual stimulus, the response gain of specific subsets of neurons in visual cortex changes. Here, we develop a functional model of population activity to investigate the structure of this effect. We fit the model to the spiking activity of bilateral neural populations in area V4, recorded while the animal performed a stimulus discrimination task under spatial attention. The model reveals four separate time-varying shared modulatory signals, the dominant two of which each target task-relevant neurons in one hemisphere. In attention-directed conditions, the associated shared modulatory signal decreases in variance. This finding provides an interpretable and parsimonious explanation for previous observations that attention reduces variability and noise correlations of sensory neurons. Finally, the recovered modulatory signals reflect previous reward, and are predictive of subsequent choice behavior.

Original languageEnglish (US)
Article numbere08998
JournaleLife
Volume4
Issue numberNOVEMBER2015
DOIs
StatePublished - Nov 2 2015

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Neurons
Sensory Receptor Cells
Population
Choice Behavior
Visual Cortex
Reward
Haplorhini
Noise
Animals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Rabinowitz, N. C., Goris, R. L., Cohen, M., & Simoncelli, E. (2015). Attention stabilizes the shared gain of V4 populations. eLife, 4(NOVEMBER2015), [e08998]. https://doi.org/10.7554/eLife.08998

Attention stabilizes the shared gain of V4 populations. / Rabinowitz, Neil C.; Goris, Robbe L.; Cohen, Marlene; Simoncelli, Eero.

In: eLife, Vol. 4, No. NOVEMBER2015, e08998, 02.11.2015.

Research output: Contribution to journalArticle

Rabinowitz, NC, Goris, RL, Cohen, M & Simoncelli, E 2015, 'Attention stabilizes the shared gain of V4 populations', eLife, vol. 4, no. NOVEMBER2015, e08998. https://doi.org/10.7554/eLife.08998
Rabinowitz NC, Goris RL, Cohen M, Simoncelli E. Attention stabilizes the shared gain of V4 populations. eLife. 2015 Nov 2;4(NOVEMBER2015). e08998. https://doi.org/10.7554/eLife.08998
Rabinowitz, Neil C. ; Goris, Robbe L. ; Cohen, Marlene ; Simoncelli, Eero. / Attention stabilizes the shared gain of V4 populations. In: eLife. 2015 ; Vol. 4, No. NOVEMBER2015.
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