Asymmetrical ventricular enlargement in Parkinson's disease

Xuemei Huang, Yueh Z. Lee, Martin McKeown, Guido Gerig, Hongbin Gu, Phd Weill Lin, Mechelle M. Lewis, Sutapa Ford, Alexander I. Tröster, Daniel R. Weinberger, Martin Styner

    Research output: Contribution to journalArticle

    Abstract

    Parkinson's disease (PD) typically manifests with asymmetric motor symptom onset. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with cognitive decline in PD, but not with motor symptom asymmetry. Asymmetrical ventricular enlargement on magnetic resonance images was explored in a monozygotic twin pair discordant for PD and in nine healthy monozygotic twin pairs. The left-right lateral ventricular volumetric difference of the PD-twin was greater than that of his twin and all other healthy twins, with the larger ventricle observed contralateral to the more symptomatic side. Moreover, the lateral ventricle asymmetry difference between twin pairs was significantly higher for the discordant PD-twin pair than for the healthy twin pairs. This is the first report to suggest the presence of asymmetrical ventricular enlargement in PD, findings that may be worthy of further study.

    Original languageEnglish (US)
    Pages (from-to)1657-1660
    Number of pages4
    JournalMovement Disorders
    Volume22
    Issue number11
    DOIs
    StatePublished - Aug 15 2007

    Fingerprint

    Parkinson Disease
    Monozygotic Twins
    Lateral Ventricles
    Atrophy
    Magnetic Resonance Spectroscopy
    Brain

    Keywords

    • Motor impairment
    • Parkinson's disease
    • Ventricle
    • Volume asymmetry

    ASJC Scopus subject areas

    • Clinical Neurology
    • Neuroscience(all)

    Cite this

    Huang, X., Lee, Y. Z., McKeown, M., Gerig, G., Gu, H., Weill Lin, P., ... Styner, M. (2007). Asymmetrical ventricular enlargement in Parkinson's disease. Movement Disorders, 22(11), 1657-1660. https://doi.org/10.1002/mds.21626

    Asymmetrical ventricular enlargement in Parkinson's disease. / Huang, Xuemei; Lee, Yueh Z.; McKeown, Martin; Gerig, Guido; Gu, Hongbin; Weill Lin, Phd; Lewis, Mechelle M.; Ford, Sutapa; Tröster, Alexander I.; Weinberger, Daniel R.; Styner, Martin.

    In: Movement Disorders, Vol. 22, No. 11, 15.08.2007, p. 1657-1660.

    Research output: Contribution to journalArticle

    Huang, X, Lee, YZ, McKeown, M, Gerig, G, Gu, H, Weill Lin, P, Lewis, MM, Ford, S, Tröster, AI, Weinberger, DR & Styner, M 2007, 'Asymmetrical ventricular enlargement in Parkinson's disease', Movement Disorders, vol. 22, no. 11, pp. 1657-1660. https://doi.org/10.1002/mds.21626
    Huang X, Lee YZ, McKeown M, Gerig G, Gu H, Weill Lin P et al. Asymmetrical ventricular enlargement in Parkinson's disease. Movement Disorders. 2007 Aug 15;22(11):1657-1660. https://doi.org/10.1002/mds.21626
    Huang, Xuemei ; Lee, Yueh Z. ; McKeown, Martin ; Gerig, Guido ; Gu, Hongbin ; Weill Lin, Phd ; Lewis, Mechelle M. ; Ford, Sutapa ; Tröster, Alexander I. ; Weinberger, Daniel R. ; Styner, Martin. / Asymmetrical ventricular enlargement in Parkinson's disease. In: Movement Disorders. 2007 ; Vol. 22, No. 11. pp. 1657-1660.
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