Astrocytic β2- Adrenergic receptors mediate hippocampal long- Term memory consolidation

Virginia Gao, Akinobu Suzuki, Pierre J. Magistretti, Sylvain Lengacher, Gabriella Pollonini, Michael Q. Steinman, Cristina Alberini

Research output: Contribution to journalArticle

Abstract

Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic receptors (ARs), of which β2- Adrenergic receptors (βARs) are of particular importance. The differential anatomical and cellular distribution of βAR subtypes in the brain suggests that they play distinct roles in memory processing, although much about their specific contributions and mechanisms of action remains to be understood. Here we show that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory. These hippocampal β2ARs, but not β1ARs, are coupled to the training-dependent release of lactate from astrocytes, which is necessary for long- Term memory formation and for underlying molecular changes. This key metabolic role of astrocytic β2ARs may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.

Original languageEnglish (US)
Pages (from-to)8526-8531
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume113
Issue number30
DOIs
StatePublished - Jul 26 2016

Fingerprint

Long-Term Memory
Adrenergic Receptors
Norepinephrine
Psychopathology
Astrocytes
Fear
Neurotransmitter Agents
Lactic Acid
Hippocampus
Hormones
Brain
Memory Consolidation

Keywords

  • Astrocyte
  • Hippocampus
  • Lactate
  • Memory
  • β- Adrenergic receptor

ASJC Scopus subject areas

  • General

Cite this

Astrocytic β2- Adrenergic receptors mediate hippocampal long- Term memory consolidation. / Gao, Virginia; Suzuki, Akinobu; Magistretti, Pierre J.; Lengacher, Sylvain; Pollonini, Gabriella; Steinman, Michael Q.; Alberini, Cristina.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 30, 26.07.2016, p. 8526-8531.

Research output: Contribution to journalArticle

Gao, Virginia ; Suzuki, Akinobu ; Magistretti, Pierre J. ; Lengacher, Sylvain ; Pollonini, Gabriella ; Steinman, Michael Q. ; Alberini, Cristina. / Astrocytic β2- Adrenergic receptors mediate hippocampal long- Term memory consolidation. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 30. pp. 8526-8531.
@article{8b3e2f89f6fb4d6daa13319cf505a67b,
title = "Astrocytic β2- Adrenergic receptors mediate hippocampal long- Term memory consolidation",
abstract = "Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic receptors (ARs), of which β2- Adrenergic receptors (βARs) are of particular importance. The differential anatomical and cellular distribution of βAR subtypes in the brain suggests that they play distinct roles in memory processing, although much about their specific contributions and mechanisms of action remains to be understood. Here we show that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory. These hippocampal β2ARs, but not β1ARs, are coupled to the training-dependent release of lactate from astrocytes, which is necessary for long- Term memory formation and for underlying molecular changes. This key metabolic role of astrocytic β2ARs may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.",
keywords = "Astrocyte, Hippocampus, Lactate, Memory, β- Adrenergic receptor",
author = "Virginia Gao and Akinobu Suzuki and Magistretti, {Pierre J.} and Sylvain Lengacher and Gabriella Pollonini and Steinman, {Michael Q.} and Cristina Alberini",
year = "2016",
month = "7",
day = "26",
doi = "10.1073/pnas.1605063113",
language = "English (US)",
volume = "113",
pages = "8526--8531",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "30",

}

TY - JOUR

T1 - Astrocytic β2- Adrenergic receptors mediate hippocampal long- Term memory consolidation

AU - Gao, Virginia

AU - Suzuki, Akinobu

AU - Magistretti, Pierre J.

AU - Lengacher, Sylvain

AU - Pollonini, Gabriella

AU - Steinman, Michael Q.

AU - Alberini, Cristina

PY - 2016/7/26

Y1 - 2016/7/26

N2 - Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic receptors (ARs), of which β2- Adrenergic receptors (βARs) are of particular importance. The differential anatomical and cellular distribution of βAR subtypes in the brain suggests that they play distinct roles in memory processing, although much about their specific contributions and mechanisms of action remains to be understood. Here we show that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory. These hippocampal β2ARs, but not β1ARs, are coupled to the training-dependent release of lactate from astrocytes, which is necessary for long- Term memory formation and for underlying molecular changes. This key metabolic role of astrocytic β2ARs may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.

AB - Emotionally relevant experiences form strong and long-lasting memories by critically engaging the stress hormone/neurotransmitter noradrenaline, which mediates and modulates the consolidation of these memories. Noradrenaline acts through adrenergic receptors (ARs), of which β2- Adrenergic receptors (βARs) are of particular importance. The differential anatomical and cellular distribution of βAR subtypes in the brain suggests that they play distinct roles in memory processing, although much about their specific contributions and mechanisms of action remains to be understood. Here we show that astrocytic rather than neuronal β2ARs in the hippocampus play a key role in the consolidation of a fear-based contextual memory. These hippocampal β2ARs, but not β1ARs, are coupled to the training-dependent release of lactate from astrocytes, which is necessary for long- Term memory formation and for underlying molecular changes. This key metabolic role of astrocytic β2ARs may represent a novel target mechanism for stress-related psychopathologies and neurodegeneration.

KW - Astrocyte

KW - Hippocampus

KW - Lactate

KW - Memory

KW - β- Adrenergic receptor

UR - http://www.scopus.com/inward/record.url?scp=84979519276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979519276&partnerID=8YFLogxK

U2 - 10.1073/pnas.1605063113

DO - 10.1073/pnas.1605063113

M3 - Article

C2 - 27402767

AN - SCOPUS:84979519276

VL - 113

SP - 8526

EP - 8531

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 30

ER -